88876-78-2Relevant academic research and scientific papers
THE USE OF 4-R1-BENZYLIDENE-4-PHENYLBENZOYLACETONITRILES FOR SYNTHESIS OF UNSYMMETRICALLY SUBSTITUTED 3,5-DICYANO-1,4-DIHYDROPYRIDINES AND 2-AMINO-4H-PYRANS
Marchalin, Stefan,Kuthan, Josef
, p. 3123 - 3129 (2007/10/02)
3,5-Dicyano-1,4-dihydropyridine derivatives III-V have been prepared by cyclocondensation of benzylidene-4-phenylbenzoylacetonitrile (Ia) with the enamines IIa-IIc.2-(4-Biphenylyl)-4-(4-R1-phenyl)-6-methyl-3,5-dicyano-1,4-dihydropyridines VI-VIII are formed by condensation of ketonitriles Ib-Id with 3-amino-2-butenenitrile(IIa).Base-catalyzed reaction of compound Ia with enaminonitrile IIa gives the adduct IX wich,on dehydration,forms 1,4-dihydropyridine III.4H-Pyrans X and XI have been prepared by cyclocondensation of ketonitrile Ia with propanedinitrile and methyl cyanoacetate,respectively.
