888944-25-0

Usage

InChI:InChI=1/C17H25N3O4/c1-17(2,3)24-16(21)19-10-8-14(9-11-19)18-12-13-4-6-15(7-5-13)20(22)23/h4-7,14,18H,8-12H2,1-3H3

Upstream product

• 189819-75-8 4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride 
• 555-16-8 4-nitrobenzaldehdye 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 888944-26-1 4-[(4-Nitro-benzyl)-(4-pentyl-benzoyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 1598416-84-2 6-methoxy-4-(2-(4-(4-nitrobenzylamino)piperidin-1-yl)ethyl)quinoline-3-carbonitrile 
• 914309-90-3 4-[(4-amino-benzyl)-tert-butoxycarbonyl-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 1189106-71-5 C₁₇H₂₇N₃O₂ 

Relevant academic research and scientific papers

Exploiting the Tolerant Region i of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility an

Diarylpyrimidine derivatives (DAPYs) exhibit robust anti-HIV-1 potency, although they have been compromised by E138K variant and severe side-effects and been suffering from poor water solubility. In the present work, hydrophilic morpholine or methylsulfon

INHIBITORS OF DNA GYRASE FOR THE TREATMENT OF BACTERIAL INFECTIONS

The present invention relates to compounds which specifically inhibit bacterial DNA Gyrase and can be used for the treatment of respiratory tract infections.

Novel 4-Aminopiperidine Derivatives

Novel substituted 4-aminopiperidine derivatives of the formula I: wherein n, R1, Y, and are as defined in claim 1, and optically pure enantiomers, mixtures of enantiomers, racemates, diastereomers, mixtures of diastereomers, diastereomeric racemates, mixtures of diastereomeric racemates and meso-forms, as well as salts and solvent complexes of such compounds, and morphological forms, that exhibit useful parasite aspartic proteases inhibiting properties and can thus be used in the form of pharmaceutical compositions as antimalarial medicines.

THIA-TETRAAZAACENAPHTHYLENE KINASE INHIBITORS

The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.