889-98-5Relevant academic research and scientific papers
Copper-Catalyzed Defluorinative Hydroarylation of Alkenes with Polyfluoroarenes
Fu, Bin,Li, Xiaohong,Xiong, Tao,Yuan, Xiuping,Zhang, Qian,Zhang, Qiao
supporting information, p. 23056 - 23060 (2020/10/19)
A catalytic defluorinative hydroarylation of alkenes with polyfluoroarenes in the presence of dppbz-ligated Cu catalyst and silanes was developed. This method provides a straightforward and alternative avenue to synthetic important polyfluorinated arenes with readily available and bench-stable alkenes as latent nucleophiles, and therefore avoids conventional reliance on stoichiometric quantities of organometallic reagents. This reaction proceeds under very mild conditions and exhibits good functional group compatibility and high level of regioselectivity. The synthetic potential of this method was further demonstrated by a gram-scale synthesis, and an array of experimental studies were also carried out to elaborate the probable mechanism.
Multicomponent Coupling Reaction of Perfluoroarenes with 1,3-Butadiene and Aryl Grignard Reagents Promoted by an Anionic Ni(II) Complex
Iwasaki, Takanori,Fukuoka, Asuka,Min, Xin,Yokoyama, Wataru,Kuniyasu, Hitoshi,Kambe, Nobuaki
supporting information, p. 4868 - 4871 (2016/10/18)
An anionic Ni complex was isolated and its structure determined by X-ray crystallography. With such an anionic complex as a key intermediate, a regio- and stereoselective multicomponent coupling reaction of perfluoroarenes, aryl Grignard reagents, and 1,3-butadiene in a 1:1:2 ratio was achieved, resulting in the formation of 1,6-octadiene derivatives containing two aryl groups, one from the perfluoroarene and the other from the aryl Grignard reagent, at the 3- and 8-positions, respectively.
Palladium-catalyzed coupling of polyfluorinated arenes with heteroarenes via C-F/C-H activation
Yu, Daohong,Lu, Long,Shen, Qilong
supporting information, p. 940 - 943 (2013/03/29)
The first palladium-catalyzed coupling of 2-pyridyl-polyfluoroarenes and benzoxazole, thiazole, benzothiazole, benzoimidazole, oxazole or oxadiazole via a concurrent C-F/C-H activation is described. Initial mechanistic studies showed that C-F activation o
