88909-85-7

Upstream product

• 88909-83-5 1-(2-nitro-cis-styryl)-naphthalene 
• 88909-83-5 1-(o-nitrostyryl)naphthalene 
• 826-74-4 1-vinylnaphthalene 
• 615-43-0 2-iodophenylamine 
• 552-89-6 2-nitro-benzaldehyde 
• 53575-08-9 diethyl 1-naphthylmethylphosphonate 
• 615-36-1 2-bromoaniline 

Downstream Products

• 88909-88-0 1-(o-acetylaminostyryl)naphthalene 

Relevant academic research and scientific papers

Metal-Free Activation of DMF by Dioxygen: A Cascade Multiple-Bond-Formation Reaction to Synthesize 3-Acylindoles from 2-Alkenylanilines

A cascade C?N, C?C and C?O multiple-bond-formation reaction to synthesize 3-acylindoles from 2-alkenylanilines with DMF (N,N-dimethylformamide) as a one-carbon synthon is described. This approach employed dioxygen as a terminal oxidant and oxygen donor, generally provided the 3-acylindoles in moderate to good yields. Moreover, the mechanistic investigation unambiguously revealed that the 2-carbon of 3-acylindole was derived from the N-methyl group of DMF. (Figure presented.).

Bi(OTf)3-mediated intramolecular hydroamination of 2-aminostilbenes for the synthesis of 2-arylindolines

An efficient Bi(OTf)3-mediated intramolecular hydroamination of 2-aminostilbenes for the synthesis of various 2-arylindolines has been developed. Various advantages using Bi(OTf)3as a catalyst, such as the operationally easy, simple, and safe procedure, good to excellent chemical yields, and the use of relatively low catalyst loading are noteworthy.

Silver(I)-mediated C-H amination of 2-alkenylanilines: Unique solvent-dependent migratory aptitude

A highly effective silver(I)-mediated C-H amination of 2-alkenylanilines has been developed to afford a diverse range of substituted indoles. High functional group tolerance, broad substrate scope, simple/fast/high-yielding reaction, and recovery/reuse of the inexpensive silver oxidant are noteworthy. Furthermore, an uncommon migratory process of β-monosubstituted 2-alkenylanilines with solvent-dependence was demonstrated.

Synthesis of 2-Substituted Indoles through Visible Light-Induced Photocatalytic Cyclizations of Styryl Azides

A visible light-induced photocatalytic intramolecular cyclization of styryl azides has been developed in the presence of the ruthenium complex Ru(bpy)3Cl2 (0.5 mol%) as photocatalyst at room temperature. The present photocatalytic strategy features operational simplicity as well as high functional group tolerance, and provides a facile access to various 2-substituted N-free indoles in good to excellent yields. Importantly, the present process can employ sunlight as the light source to afford the corresponding products without loss of reaction efficiency.

Metal-free C-H amination for indole synthesis

An effective metal-free C-H amination of N-Ts-2-alkenylanilines by using DDQ as an oxidant has been developed to afford a diverse range of substituted indoles. This protocol is operationally simple and robust, obviates the need of expensive transition-metal catalysts, and offers a broad substrate scope. A mechanism involving a radical cation generated by SET and a migratorial process via a phenonium ion intermediate is proposed.

Synthesis of aminochrysenes by the oxidative photocyclization of acetylaminostilbenes

Aminochrysene derivatives were synthesized by the oxidative photocyclization of acetylaminostilbenes in the presence of iodine and air, followed by hydrolysis.