88909-96-0Relevant articles and documents
Synthesis and photophysical properties of multichromophoric carbonyl-bridged triarylamines
Haedler, Andreas T.,Beyer, Sebastian R.,Hammer, Natalie,Hildner, Richard,Kivala, Milan,K?hler, Jürgen,Schmidt, Hans-Werner
, p. 11708 - 11718 (2014)
The synthesis and photophysical properties of two novel multichromophoric compounds is presented. Their molecular design comprises a carbonyl-bridged triarylamine core and either naphthalimides or 4-(5-hexyl-2,2 -bithiophene)naphthalimides as second chrom
Cystine-derived bis-naphthalimides as stimuli-responsive fluorescent gelators
Sarma, Rupam J.,Devi, Kakali
, p. 4375 - 4383 (2015)
Two cystine-derived bis-naphthalimide gelators (L1, L2) were synthesised and characterised. Both L1 and L2 exhibited similar absorptions and emission spectra in solvents such as acetonitrile and DMF. The fluorescence spectra of both the compounds featured a distinct monomer and long-wavelength excimer emissions in the aforementioned solvents. It was found that the excimer emissions for the two compounds could be preferentially quenched by triethylamine, and subsequently restored with hydrofluoric acid. The stimuli-responsive nature of the excimer emissions was demonstrated using anion stimuli in solution and in the gel phase. Thus, the excimer emission for L1 (or L2) could be switched 'off' using fluoride anions, and subsequently re-activated using tetrafluoroborate anions as the chemical stimulus.
Target Enzyme-Activated Two-Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two-Dimensional Design Strategy
Ning, Jing,Wang, Wei,Ge, Guangbo,Chu, Peng,Long, Feida,Yang, Yongliang,Peng, Yulin,Feng, Lei,Ma, Xiaochi,James, Tony D.
supporting information, p. 9959 - 9963 (2019/06/24)
The rapid development of fluorescent probes for monitoring target enzymes is still a great challenge owing to the lack of efficient ways to optimize a specific fluorophore. Herein, a practical two-dimensional strategy was designed for the development of an isoform-specific probe for CYP3A4, a key cytochrome P450 isoform responsible for the oxidation of most clinical drugs. In first dimension of the design strategy, a potential two-photon fluorescent substrate (NN) for CYP3A4 was effectively selected using ensemble-based virtual screening. In the second dimension, various substituent groups were introduced into NN to optimize the isoform-selectivity and reactivity. Finally, with ideal selectivity and sensitivity, NEN was successfully applied to the real-time detection of CYP3A4 in living cells and zebrafish. These findings suggested that our strategy is practical for developing an isoform-specific probe for a target enzyme.
Naphthalimide Platinum(IV) Compounds as Antitumor Agents with Dual DNA Damage Mechanism to Overcome Cisplatin Resistance
Wang, Qingpeng,Li, Guoshuai,Liu, Zhifang,Tan, Xiaoxiao,Ding, Zhuang,Ma, Jing,Li, Lanjie,Li, Dacheng,Han, Jun,Wang, Bingquan
supporting information, p. 4442 - 4451 (2018/10/25)
A new series of naphthalimide platinum(IV) compounds with dual DNA damage mechanism were designed, synthesized and evaluated for antitumor activities. The platinum(IV) compounds could combine with DNA and cause DNA damage via naphthalimide fragment. Then the platinum(II) complexes released in reductive microenvironment would cause remarkable secondary DNA lesions. Some title compounds exhibit good antitumor activities and are of great potential in overcoming the drug resistance of cisplatin. Furthermore, naphthalimide platinum(IV) complexes could effectively combine with HSA by electrostatic force, which would influence the drug distribution and bioactivities in vivo. Moreover, the accumulation of the tested platinum(IV) compounds in whole cells and DNA is remarkably enhanced in comparison with cisplatin and oxaliplatin.
Structures of bifunctional molecules containing two very different supramolecular synthons: Carboxylic acid and strong π...π stacking 1,8-naphthalimide ring
Reger, Daniel L.,Debreczeni, Agota,Horger, Jacob J.,Smith, Mark D.
scheme or table, p. 4068 - 4079 (2012/03/13)
A series of molecules containing a carboxylic acid and a 1,8-naphthalimide group joined by different linkers (HLC1 = CH2; HL C2 = CH2CH2; HLC3 = CH 2CH2CH2;
METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
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Page/Page column 25; 48-50, (2009/04/24)
Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.
Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors
David-Cordonnier, Marie-Helene,Hildebrand, Marie-Paule,Baldeyrou, Brigitte,Lansiaux, Amelie,Keuser, Christoph,Benzschawel, Kerstin,Lemster, Thomas,Pindur, Ulf
, p. 752 - 771 (2008/02/13)
In the context of the design and synthesis of minor groove binding and intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. These hybrid molecules (combilexins) possess a variable and conformatively flexible spacer at the N-terminal end. As intercalating tricyclic systems acridone, acridine, anthraquinones and in a special case iminostilbene terminate the N-terminal end of the pyrrole chain. The cytotoxicity was examined by the NCI antitumor screening, furthermore, biophysical as well as biochemical studies were performed in order to get some information about the DNA binding properties and topoisomerase inhibition effect of this new series of molecules.
Synthesis of 2′-amino-2′-deoxyuridine modified by 1,8-naphthalimide
Li, Heting,Jiang, Zhiqin,Wang, Xin,Zheng, Chao
, p. 1933 - 1940 (2007/10/03)
A simple and efficient synthetic route of 2′-amino-2′- deoxyuridine was studied. 2′-Amino-2′-deoxyuridine was incorporated into 1,8-naphthalimides in the 2′-position of 2′-sugar via linking arms of different lengths. A convenient method for the synthesis of the conjugates was adopted. Copyright Taylor & Francis Group, LLC.
