150705-10-5

Basic information

• Product Name: AKOS BBS-00007386
• Synonyms: AKOS BBS-00007386;Ethyl 4-{2,4-dioxo-3-azatricyclo[7.3.1.0^{5,13}]-trideca-1(13),5,7,9,11- pentaen-3-yl}butanoate;Ethyl 4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butanoate;Ethyl 4-{2,4-dioxo-3-azatricyclo[7.3.1.0^{5,13}]-trideca-1(13),5,7,9,11- pentaen-3-yl}butanoat
• CAS NO: 150705-10-5
• Molecular Formula: C18H17NO4
• Molecular Weight: 311.33188
• Mol File: 150705-10-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 484.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.277±0.06 g/cm3(Predicted)
• PKA: -2.19±0.20(Predicted)
• CAS DataBase Reference: AKOS BBS-00007386(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BBS-00007386(150705-10-5)
• EPA Substance Registry System: AKOS BBS-00007386(150705-10-5)

Safety Data

• Hazardous Substances Data: 150705-10-5(Hazardous Substances Data)

Upstream product

• 51411-04-2 alrestatin 
• 140-88-5 ethyl acrylate 
• 3153-36-4 4-chloro-butyric acid ethyl ester 
• 81-83-4 1,8-Naphthalimide 
• 2969-81-5 Ethyl 4-bromobutyrate 

Downstream Products

• 88909-96-0 4-(1,3-dioxo-2,3-dihydro-1H-benzo[d,e]isoquinolin-2-yl)butanoic acid 

Relevant articles and documents

Photoinduced Decarboxylative Radical Addition Reactions for Late Stage Functionalization of Peptide Substrates

Photoredox chemistry has greatly stimulated the application of radical based transformations in medicinal chemistry and early drug discovery in recent years. Carboxylate groups have been identified as traceless leaving groups that can be converted into radical intermediates capable of undergoing 1,4-conjugate addition reactions to Michael acceptors. Herein, we show the successful C-terminal derivatization of small peptide substrates by using this methodology in a parallel synthesis setting. Finally, we outline a general strategy for the γ-homologation of several drugs derived from α-amino acids in a late stage functionalization (LSF) approach.

Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors

In the context of the design and synthesis of minor groove binding and intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. These hybrid molecules (combilexins) possess a variable and conformatively flexible spacer at the N-terminal end. As intercalating tricyclic systems acridone, acridine, anthraquinones and in a special case iminostilbene terminate the N-terminal end of the pyrrole chain. The cytotoxicity was examined by the NCI antitumor screening, furthermore, biophysical as well as biochemical studies were performed in order to get some information about the DNA binding properties and topoisomerase inhibition effect of this new series of molecules.