889103-63-3

Upstream product

• 100-52-7 benzaldehyde 
• 211183-18-5 hydrogen di[(1R,2S,5R)-menthyl] phosphite 
• 741292-48-8 di-(1R,2S,5R)-menthyl benzoylphosphonate 

Downstream Products

• 211134-57-5 (-)-di-[(1R,2S,5R)-menth-2-yl] (α-hydroxybenzyl)phosphonate 
• 889103-61-1 di-(1R,2S,5R)-menthyl (S)-1-phenyl-1-hydroxymethylphosphonate 
• 741292-48-8 di-(1R,2S,5R)-menthyl benzoylphosphonate 

Relevant academic research and scientific papers

Catalytic synthesis of α-hydroxyphosphonates

Reactions of carbonyl compounds of aliphatic, aromatic, and heteroaromatic series with dialkyl phosphites in the presence of DBN were studied under microwave irradiation.

Efficient method for the asymmetric reduction of α- and β-ketophosphonates

An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant derived from sodium borohydride and l-(+)- or d-(-)-tartaric acid is developed. The methodology was used for the preparation of a number of biologically interesting enantiomerically pure products: including 2,3-epoxypropylphosphonate 11, 2-hydroxy-3-aminopropylphosphonic acid 14 (phospho-GABOB), phospho-carnitine 19, and others in multigram scale.

Enantioselective reduction of ketophosphonates using chiral acid adducts with sodium borohydride

A method for asymmetric reduction of α-and β-ketophosphonates using a chiral complex prepared from sodium borohydride and D-or L-tartaric acid is developed. Reduction of α-or β-ketophosphonates by these reagents led to formation of corresponding (S)-or (R