889108-58-1Relevant articles and documents
Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions
Henon, Helene,Anizon, Fabrice,Golsteyn, Roy M.,Leonce, Stephane,Hofmann, Robert,Pfeiffer, Bruno,Prudhomme, Michelle
, p. 3825 - 3834 (2007/10/03)
The syntheses of a series of dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted in 10-position with saturated and unsaturated side chains, via palladium catalyzed cross-coupling reactions, are described. These compounds can be considered as granulatimide bis-imide analogues. Their inhibitory activity toward Chk1 kinase and their antiproliferative activities in vitro in four tumor cell lines are reported.