91459-41-5Relevant academic research and scientific papers
Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides
Liao, Jennie,Basch, Corey H.,Hoerrner, Megan E.,Talley, Michael R.,Boscoe, Brian P.,Tucker, Joseph W.,Garnsey, Michelle R.,Watson, Mary P.
supporting information, p. 2941 - 2946 (2019/04/30)
A nickel-catalyzed reductive cross-coupling of alkylpyridinium salts and aryl bromides has been developed using Mn as the reductant. Both primary and secondary alkylpyridinium salts can be used, and high functional group and heterocycle tolerance is observed, including for protic groups. Mechanistic studies indicate the formation of an alkyl radical, and controlling its fate was key to the success of this reaction.
Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions
Henon, Helene,Anizon, Fabrice,Golsteyn, Roy M.,Leonce, Stephane,Hofmann, Robert,Pfeiffer, Bruno,Prudhomme, Michelle
, p. 3825 - 3834 (2007/10/03)
The syntheses of a series of dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted in 10-position with saturated and unsaturated side chains, via palladium catalyzed cross-coupling reactions, are described. These compounds can be considered as granulatimide bis-imide analogues. Their inhibitory activity toward Chk1 kinase and their antiproliferative activities in vitro in four tumor cell lines are reported.
5-HT-1D receptor ligands
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, (2008/06/13)
Described herein are tryptamine analogs that display high binding affinity and selectivity for the 5-HT1Dβ receptor, of the formula: STR1 wherein R 1 is a group selected from aryl-C 1-7 alkyl; aryl-C 2-7 alkoxy; aryl-C 2-7 alkanoyl and aryl-C 1-7 alkanoyloxy, wherein said alkyl, alkoxy, alkanoyl and alkanoyloxy groups are optionally substituted by a C 1-4 alkyl substituent and wherein said aryl group is optionally substituted by one or more substituent selected from hydroxyl, halogen, mercapto, linear or branched C 1-4 alkyl, linear or branched C 1-4 alkoxy, linear or branched C 1-4 alkylthio, thiol substituted C 1-4 alkyl and nitro substituted C 1-4 alkyl;R 2 and R 3 are selected independently from H and C 1-4 alkyl; andR 4 is selected from H, C 1-4 alkyl, aryl and arylC 1-4 alkyl. The compounds are useful as reagents for receptor identification and in receptor-based drug screening programs, and can also be used therapeutically to treat conditions for which administration of a 5-HT1D ligand is indicated, for example in the treatment of migraine.
Binding of 5-Arylalkyloxytryptamines at Human 5-HT1Dβ Serotonin Receptors
Hong, Seoung-Soo,Dukat, Malgorzata,Teitler, Milt,Herrick-Davis, Kathy,McCallum, Kirk,et al.
, p. 690 - 699 (2007/10/03)
Several 5-substituted tryptamine derivatives were prepared and examined for their binding at 5-HT1D serotonin receptors. Initially, a region of bulk tolerance was probed. Subsequently, a series of 5-(arylalkyloxy)tryptamines was prepared. Within a homolog
INDOLE DERIVATIVES. 124. 5-(2-PHENYLETHENYL)INDOLINES AND 5-(2-PHENYLETHENYL)INDOLES
Chupina, L. N.,Shner, V. F.,Gritsina, G. I.,Terekhina, A. I.,Suvorov, N. N.
, p. 372 - 375 (2007/10/02)
5-(2-Phenylethenyl)indolines, the dehydrogenation of wich leads to the formation of the corresponding compounds of the indole series, were obtained from 5-formyl-1-methyl(or benzyl)indolines via the Grignard reaction with benzylmagnesium chloride and subs
