88912-02-1Relevant academic research and scientific papers
CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Paragraph 0001482; 0001483; 0001594-0001596, (2018/01/17)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.
Discovery and Optimization of a Porcupine Inhibitor
Duraiswamy, Athisayamani Jeyaraj,Lee, May Ann,Madan, Babita,Ang, Shi Hua,Tan, Eldwin Sum Wai,Cheong, Wei Wen Vivien,Ke, Zhiyuan,Pendharkar, Vishal,Ding, Li Jun,Chew, Yun Shan,Manoharan, Vithya,Sangthongpitag, Kanda,Alam, Jenefer,Poulsen, Anders,Ho, Soo Yei,Virshup, David M.,Keller, Thomas H.
, p. 5889 - 5899 (2015/08/24)
Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleate
