889125-79-5Relevant academic research and scientific papers
Anthranilamide inhibitors of factor Xa
Mendel, David,Marquart, Angela L.,Joseph, Sajan,Waid, Philip,Yee, Ying K.,Tebbe, Anne Louise,Ratz, Andrew M.,Herron, David K.,Goodson, Theodore,Masters, John J.,Franciskovich, Jeffry B.,Tinsley, Jennifer M.,Wiley, Michael R.,Weir, Leonard C.,Kyle, Jeffrey A.,Klimkowski, Valentine J.,Smith, Gerald F.,Towner, Richard D.,Froelich, Larry L.,Buben, John,Craft, Trelia J.
, p. 4832 - 4836 (2008/02/11)
SAR about the B-ring of a series of N2-aroyl anthranilamide factor Xa (fXa) inhibitors is described. B-ring o-aminoalkylether and B-ring p-amine probes of the S1′ and S4 sites, respectively, afforded picomolar fXa inhibitors that performed well in in vitro anticoagulation assays.
AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS
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Page/Page column 284, (2008/06/13)
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
