889140-40-3

Upstream product

• 947594-73-2 3,4-dichlorophenacyl azide ethylene ketal 
• 297765-44-7 2-azido-1-(3,4-dichlorophenyl)ethanone 
• 2632-10-2 2-bromo-1-(3,4-dichlorophenyl)ethanone 

Downstream Products

• 947594-82-3 3β-(4-chlorophenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal 
• 947595-17-7 3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxamide ethylene ketal 
• 947595-18-8 3β-(4-methylphenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxthioamide ethylene ketal 
• 947594-83-4 3β-(4-chlorophenyl)tropane-2β-N-(3,4-dichlorophenacyl)carboxthioamide ethylene ketal 

Relevant academic research and scientific papers

Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3β-[4-methylphenyl and 4-chlorophenyl]- 2β-[5-(substituted phenyl)thiazol-2-yl]tropanes

Synthetic methods were developed for the synthesis of the 3β-(4-substituted phenyl)-2β-[5-(substituted phenyl)thiazol-2-yl] tropanes (4a-s). The compounds were evaluated for their monoamine transporter binding and monoamine uptake inhibition properties using both rat brain tissue and cloned transporter assays. In general, the compounds showed higher dopamine transporter (DAT) affinity relative to the serotonin and norepinephrine transporters (SERT and NET, respectively) and greater [3H]dopamine uptake inhibition potency relative to [3H]serotonin and [ 3H]norepinephrine uptake inhibition. Several compounds were DAT selective relative to the SERT and NET in the monoamine transporter binding assays. The most potent and selective analog in the functional monoamine uptake inhibition test was 3β-(4-methylphenyl-2β-[5-(3-nitrophenyl)thiazol-2- yl]tropane (4p).

INDOLE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or