88920-78-9

Basic information

• Product Name: 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE OXIME
• Synonyms: AKOS B006535;1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE OXIME;ART-CHEM-BB B006535;BUTTPARK 94\04-93;3,4-DIMETHOXYACETOPHENONE OXIME
• CAS NO: 88920-78-9
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 88920-78-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 147 °C
• Boiling Point: 321.3°C at 760 mmHg
• Flash Point: 148.1°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE OXIME(88920-78-9)
• EPA Substance Registry System: 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE OXIME(88920-78-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 88920-78-9(Hazardous Substances Data)

Usage

General Description

1-(3,4-Dimethoxyphenyl)ethan-1-one oxime, also known as 3,4-dimethoxybenzophenone oxime, is a synthetic compound that belongs to the family of oximes. It is a derivative of benzophenone, and is commonly used in organic synthesis as a reagent for the formation of oximes, which are important intermediates in the preparation of various organic compounds. 1-(3,4-Dimethoxyphenyl)ethan-1-one oxime has a molecular formula of C10H13NO3 and a molecular weight of 195.21 g/mol. It is a crystalline solid with a white to off-white color, and is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone. 1-(3,4-DIMETHOXYPHENYL)ETHAN-1-ONE OXIME is known for its role in pharmaceutical and medicinal chemistry, as well as in the production of various industrial chemicals.

InChI:InChI=1/C10H13NO3/c1-7(11-12)8-4-5-9(13-2)10(6-8)14-3/h4-6,12H,1-3H3

Upstream product

• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 32953-13-2 3,4-dimethoxy-phenylethylamine 
• 141339-27-7 N-(α-(3,4-dimethoxyphenyl)ethyl)hydroxylamine 
• 1233087-30-3 1-(3,4-dimethoxyphenyl)ethanone O-6-(2-methyl-4-nitro-1H-imidazol-1-yl)hexyloxime 
• 1376770-98-7 1-(3,4-dimethoxyphenyl)-4-hydroxy-4-phenyl-butan-1-one 
• 1376770-93-2 3-(3,4-dimethoxyphenyl)-6-phenyl-5,6-dihydro-4H-[1,2]oxazine 
• 27922-95-8 6,7-dimethoxy-1-methyl-3,4-diphenylisoquinoline 
• 943963-86-8 3'-(3,4-dimethoxyphenyl)spiro[1,2-benzoisothiazole-3,5'(4'H)-isoxazole] 1,1-dioxide 
• 1019628-47-7 N-<3,4-Dimethoxy-α-methyl-benzyl>-glycin-methyl-ester 

Relevant articles and documents

Access to pyrrolo[2,1-: A] isoindolediones from oxime acetates and ninhydrin via Cu(i)-mediated domino annulations

A copper-mediated domino condensation reaction of readily accessible oxime acetates with ninhydrin is reported to afford pyrrolo[2,1-a]isoindolediones via new C-C & C-N bond formations. A wide range of oxime acetates were shown to generally participate in the reaction to produce the condensed products in excellent yields. The necessary control experiments were performed and the mechanism is proposed to involve sequentially the formation of iminium radical via Cu-mediated N-O bond cleavage of oxime acetates, addition of the radical to ninhydrin and rearrangement via ring expansion.

SO2F2-Activated Efficient Beckmann Rearrangement of Ketoximes for Accessing Amides and Lactams

A novel, mild and practical protocol for the efficient activation of the Beckmann rearrangement utilizing the readily available and economical sulfuryl fluoride (SO2F2 gas) has been developed. The substrate scope of the operationally simple methodology has been demonstrated by 37 examples with good to nearly quantitative isolated yields (over 90 % yield in most cases) in a short time, including B(OH)2, COOH, NH2, and OH substituted substrates. A tentative mechanism was proposed involving formation and elimination of key intermediate, sulfonyl ester.

Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes

Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.