88932-14-3Relevant academic research and scientific papers
HARMINE DERIVATIVES, INTERMEDIATES USED IN THEIR PREPARATION, PREPARATION PROCESSES AND USE THEREOF
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Page/Page column 20; 21, (2008/06/13)
This invention relates to compounds of general formula (I), wherein R1, R2, R3, R4 and R5 are as defined specification; intermediates used in their preparation, preparation processes and use thereof. The present invention produce harmine derivatives with enhanced antihumour activity and lower nervous system toxicity by structurally modification parent structure of β-carboline of harmines at position 1, 2, 3, 7 and 9, The compounds of the present invention can be pre easily with high yield. They can be used in manufacture of a variety of antitumour medicines and medicines used in treatm tumour diseases in combination of light or radiation therapy.
Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives
Cao,Chen,Peng,Ma,Hou,Guan,Liu,Xu
, p. 991 - 1001 (2007/10/03)
To further our SAR study on the chemistry and antitumor activity/neurotoxicity of β-carboline alkaloids, several series of β-carboline derivatives with various substituents were designed and synthesized from the starting material l-tryptophan on the basis
Non-peptide antagonists of GLP-1 receptor and methods of use
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, (2008/06/13)
Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding
