88932-67-6Relevant academic research and scientific papers
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
Zhang, Lei,Chen, Xiaojie,Liu, Jun,Zhu, Qingzhang,Leng, Ying,Luo, Xiaomin,Jiang, Hualiang,Liu, Hong
, p. 624 - 639 (2013/02/21)
Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, therefore allow for a better control over hyperglycaemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds (1j, 6g) worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references.
Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: Direct asymmetric aldol reaction
Daka, Philias,Xu, Zhenghu,Alexa, Alexandru,Wang, Hong
supporting information; experimental part, p. 224 - 226 (2011/03/19)
A novel class of primary amine-metal Lewis acid bifunctional catalysts based on a bidentate ligand was developed. These catalysts were highly efficient in catalyzing the direct asymmetric aldol reactions of ketones offering excellent stereoselectivity. Th
Synthesis of Pyridine Derivatives of L-Phenylalanine as Antisickling Reagents
Altman, Janina,Gorecki, Marian,Wilchek, Meir,Votano, Joseph R.,Rich, Alexander
, p. 596 - 600 (2007/10/02)
Several bicyclic agents composed of L-phenylalanine coupled to various pyridines were synthesized: 2-, 3-, and 4-(L-phenylalanylamino)pyridine.All three compounds at 3 mM gave positive morphological antisickling effects on homozygous SS cells under reduce
