88932-73-4Relevant academic research and scientific papers
Synthesis of chiral amino acid anilides by ligand-free copper-catalyzed selective N-arylation of amino acid amides
Dong, Junyu,Wang, Yan,Xiang, Qinjie,Lv, Xirui,Weng, Wen,Zeng, Qingle
supporting information, p. 692 - 696 (2013/04/11)
An atom-economic, practical and cost-effective protocol for synthesis of chiral amino acid anilides via ligand-free copper-catalyzed selective C-N cross coupling of chiral amino acid amides and aryl halides, hetereoaryl halides and a vinyl bromide has been developed. No racemization occurred during the C-N coupling. A plausible mechanism is proposed. Copyright
Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase
Zhang, Lei,Chen, Xiaojie,Liu, Jun,Zhu, Qingzhang,Leng, Ying,Luo, Xiaomin,Jiang, Hualiang,Liu, Hong
, p. 624 - 639 (2013/02/21)
Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, therefore allow for a better control over hyperglycaemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds (1j, 6g) worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references.
Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: Direct asymmetric aldol reaction
Daka, Philias,Xu, Zhenghu,Alexa, Alexandru,Wang, Hong
, p. 224 - 226 (2011/03/19)
A novel class of primary amine-metal Lewis acid bifunctional catalysts based on a bidentate ligand was developed. These catalysts were highly efficient in catalyzing the direct asymmetric aldol reactions of ketones offering excellent stereoselectivity. Th
Synthesis and analgesic activities of urea derivatives of α-amino-N-pyridyl benzene propanamide
Sartori, E.,Camy, F.,Teulon, J. M.,Camborde, F.,Meignen, J.,at el.
, p. 431 - 440 (2007/10/02)
New urea L-phenyl alanine derivatives of 4-aminopyridine have been synthesized and evaluated for analgesic activity with the PBQ writhing test in mice and the Randall-Selitto test in rats.Potent oral activity (ID50 10 mg/kg) and good tolerance were foun
