889447-19-2

Basic information

• Product Name: 2-chloro-5H-pyrrolo[2,3-b]pyrazine
• Synonyms: 2-chloro-5H-pyrrolo[2,3-b]pyrazine;2-Chloro-5H-pyrrolo[2,3-b...;2-chloro-5H-pyrrolo[2;5H-Pyrrolo[2,3-b]pyrazine, 2-chloro-;2-chloro-5H-pyrrolo[3,2-b]pyrazine
• CAS NO: 889447-19-2
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.5691
• Product Categories: CHIRAL CHEMICALS
• Mol File: 889447-19-2.mol

Chemical Properties

• Appearance: /
• Density: 1.531 g/cm³
• Refractive Index: 1.72
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.63±0.50(Predicted)
• CAS DataBase Reference: 2-chloro-5H-pyrrolo[2,3-b]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5H-pyrrolo[2,3-b]pyrazine(889447-19-2)
• EPA Substance Registry System: 2-chloro-5H-pyrrolo[2,3-b]pyrazine(889447-19-2)

Safety Data

• Hazardous Substances Data: 889447-19-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-chloro-5H-pyrrolo[2,3-b]pyrazine is used as a reactive intermediate for the synthesis of more complex molecules in the chemical industry. Its chlorine atom makes it a versatile building block that can be further modified through substitution reactions.
Used in Pharmaceutical Research:
In the field of pharmaceuticals, 2-chloro-5H-pyrrolo[2,3-b]pyrazine is used as a starting material for the development of potential drug candidates. Its unique structure may offer opportunities for the creation of new therapeutic agents, particularly in the area of heterocyclic chemistry.
Used in Material Science:
2-chloro-5H-pyrrolo[2,3-b]pyrazine is employed as a component in the development of new materials with specific properties, such as conductivity or stability. Its reactivity and structural characteristics make it a candidate for use in the creation of advanced materials for various applications.
Note: The uses listed above are speculative based on the compound's chemical properties and are provided as examples. The actual applications may vary and are likely to be found in more specialized or niche areas of research and development.

InChI:InChI=1/C6H4ClN3/c7-5-3-9-6-4(10-5)1-2-8-6/h1-3H,(H,8,9)

Upstream product

• 1244776-64-4 5-chloro-3-((trimethylsilyl)ethynyl)pyrazine-2-amine 
• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 
• 889447-18-1 5-chloro-3-(triethyl-silanylethynyl)-pyrazin-2-ylamine 

Downstream Products

• 889447-20-5 2-chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine 
• 1262310-65-5 2-chloro-7-iodo-5-(phenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine 
• 1262310-67-7 trans-4-(6-chloro-4-(2-chloro-5-(phenylsulfonyl)-5H-pyrrolo[3,2-b]pyrazin-7-yl)pyridin-2-ylamino)cyclohexanol 
• 1262310-64-4 trans-4-{[6-chloro-4-(2-chloro-5H-pyrrolo[2,3-b]pyrazin-7-yl)pyridin-2-yl]amino}cyclohexanol 

Relevant articles and documents

INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES

The present invention relates to heteroaryl compounds of formula (Ia) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer,an isotopic form, a N-oxide or a S-oxide thereof. The present invention further relates to the use of a compound of formula (I) or an agriculturally acceptable salt, a stereoisomer, a tautomer, an isotopic form, a derivative or mixture thereof, as fungicide.

Influenza virus replication inhibitors and uses thereof (by machine translation)

The invention provides a compound as an influenza virus replication inhibitor, a method for preparing the same, a pharmaceutical composition containing the compound and application. (by machine translation)

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Influenza virus replication inhibitor and application thereof

The invention provides a type of compounds serving as an influenza virus replication inhibitor, a preparation method of the compounds, a pharmaceutical composition comprising the compounds, and application of the compounds and the pharmaceutical composition thereof in treatment of influenza.

Compounds used as JAK inhibitor, and use of compounds

The invention provides compounds used as a JAK inhibitor, and a use of the compounds, and concretely provides compounds (represented by formula (I)) with JAK inhibition activity or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a medicinal composition including the compounds. The invention also discloses a use of the compounds or the medicinal composition thereof in the preparation of medicines used for treating autoimmune diseases or proliferative diseases.

INHIBITORS OF INFLUENZA VIRUSES REPLICATION

Compound according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. Uses of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient.