889447-20-5

Usage

Uses

Used in Pharmaceutical Research:
2-Chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine is utilized as a building block in the synthesis of biologically active molecules, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of diverse compounds with potential therapeutic applications.
Used in Chemical Research:
In the realm of chemical research, 2-Chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine functions as a reagent in various chemical reactions. Its reactivity with different chemical entities makes it instrumental in the synthesis of a wide array of organic compounds, expanding the scope of chemical synthesis and innovation.
Used in Medicinal Chemistry:
2-Chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine holds significant potential in medicinal chemistry, where it is employed for the synthesis of compounds with specific biological activities. Its role in creating molecules that can interact with biological targets makes it a key component in the advancement of new therapeutic agents.

InChI:InChI=1S/C6H3ClIN3/c7-4-2-10-6-5(11-4)3(8)1-9-6/h1-2H,(H,9,10)

Upstream product

• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 
• 1244776-64-4 5-chloro-3-((trimethylsilyl)ethynyl)pyrazine-2-amine 
• 889447-19-2 2-chloro-5H-pyrrolo[2,3-b]pyrazine 

Downstream Products

• 889447-21-6 2-chloro-7-iodo-5-(toluene-4-sulfonyl)-5H-pyrrolo[2,3-b]pyrazine 

Relevant academic research and scientific papers

INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES

The present invention relates to heteroaryl compounds of formula (Ia) or a compound in the form of a stereoisomer, an agriculturally acceptable salt, a tautomer,an isotopic form, a N-oxide or a S-oxide thereof. The present invention further relates to the use of a compound of formula (I) or an agriculturally acceptable salt, a stereoisomer, a tautomer, an isotopic form, a derivative or mixture thereof, as fungicide.

Influenza virus replication inhibitors and uses thereof (by machine translation)

The invention provides a compound as an influenza virus replication inhibitor, a method for preparing the same, a pharmaceutical composition containing the compound and application. (by machine translation)

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Influenza virus replication inhibitor and application thereof

The invention provides a type of compounds serving as an influenza virus replication inhibitor, a preparation method of the compounds, a pharmaceutical composition comprising the compounds, and application of the compounds and the pharmaceutical composition thereof in treatment of influenza.

Compounds used as JAK inhibitor, and use of compounds

The invention provides compounds used as a JAK inhibitor, and a use of the compounds, and concretely provides compounds (represented by formula (I)) with JAK inhibition activity or a stereoisomer, a geometric isomer, a tautomer, a racemate, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a medicinal composition including the compounds. The invention also discloses a use of the compounds or the medicinal composition thereof in the preparation of medicines used for treating autoimmune diseases or proliferative diseases.

INHIBITORS OF INFLUENZA VIRUSES REPLICATION

Compound according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. Uses of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient.

PYRROLOPYRAZINE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.

PYRROLOPYRAZINES AND PYRAZOLOPYRAZINES USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds of formula (I): wherein x, R1, R2 and R3 denote as in Claim 1, useful as inhibitors of Aurora protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of usig the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.