889455-74-7Relevant academic research and scientific papers
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors
Guare, James P.,Wai, John S.,Gomez, Robert P.,Anthony, Neville J.,Jolly, Samson M.,Cortes, Amanda R.,Vacca, Joseph P.,Felock, Peter J.,Stillmock, Kara A.,Schleif, William A.,Moyer, Gregory,Gabryelski, Lori J.,Jin, Lixia,Chen, I-Wu,Hazuda, Daria J.,Young, Steven D.
, p. 2900 - 2904 (2006)
A series of 5-amino derivatives of 8-hydroxy[1,6]-naphthyridine-7-carboxamide exhibiting sub-micromolar potency against replication of HIV-1 in cell culture was identified. One of these analogs, compound 12, displayed excellent pharmacokinetic properties
