88952-37-8

Upstream product

• 4010-25-7 2-acetyl-4-methylphenyl 4-methylbenzoate 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 874-60-2 4-methyl-benzoyl chloride 
• 106-44-5 p-cresol 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 99-94-5 p-Toluic acid 

Downstream Products

• 136764-52-8 1a,7a-Dihydro-5-methyl-1a-(4-methylphenyl)-7H-oxireno<1>benzopyran-7-one 
• 78396-37-9 4',6-Dimethyl-3-hydroxyflavone 
• 88952-74-3 6-methyl-2-(p-tolyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

Transition-Metal-Free Photoinduced Intramolecular Annulation of 2,3-Di(hetero)arylchromen-4-one

An efficient transition-metal-free photoinduced intracyclization of 4H-chromen-4-ones in EtOH-H2O (7:1, v/v) at ambient temperature for the construction of complicated fused-ring heteroaromatics is established. The reaction proceeds smoothly without requiring any catalysts/additives.

Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABAA receptor

To further develop and evaluate a pharmacophore model previously proposed by Cook and co-workers (Drug Des. Discovery 1995, 12, 193-248) for ligands binding to the benzodiazepine site of the GABAA receptor, 40 new flavone derivatives have been synthesized and their affinities for the benzodiazepine site have been determined. Two new regions of steric repulsive interactions between ligand and receptor have been characterized, and the receptor region in the vicinity of 6- and 3′-substituents has been mapped out. 2′-Hydroxy substitution is shown to give a significant increase in affinity, which is interpreted in terms of a novel hydrogen bond interaction with the previously proposed hydrogen bond-accepting site A2. On the basis of the results of these studies and the refined pharmacophore model, 5′-bromo-2′-hydroxy-6-methylflavone, the highest affinity flavone derivative reported so far (Ki = 0.9 nM), was successfully designed. A comparison of the pharmacophore model with a recently proposed alternative model (Marder; et al. Bioorg. Med. Chem., 2001, 9, 323-335) has been made.

Epoxidation of Flavones by Dimethyldioxirane

The synthesis of epoxides 2 by epoxidation of flavones 1 with isolated dimethyldioxirane (as acetone solution) at subambient temperatures is reported.These labile epoxides were isolated and completely characterized by UV, IR, 1H and 13C NMR, MS, and C,H analyses.Warming to room temperature led to rearrangement to afford quantitatively the 3-hydroxyflavones 3b,h,i,n.Treatment of the epoxides 2b,f with methanol led to the 3-hydroxy-2-methoxyflavanones 4b,f, as a mixture of cis and trans isomers.

Synthesis and Screening of Some 1,3-Propane Diones and Flavones

Variously substituted 1,3-propane diones and flavones are synthesized.Structures of the compounds are established by chemical and spectral data.The compounds are tested for antifungal and antibacterial activities.