88958-19-4

Usage

General Description

1H-1,2,3-Triazole-4-carbonyl chloride, 5-methyl-1-(3-methylphenyl)- is a chemical compound that contains a triazole ring and a carbonyl chloride group. It also has a methyl group and a 3-methylphenyl group attached to it. 1H-1,2,3-Triazole-4-carbonyl chloride, 5-methyl-1-(3-methylphenyl)- is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a useful building block in the synthesis of diverse organic compounds. Its properties and potential applications make it a valuable and versatile chemical in the field of organic chemistry.

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 4113-72-8 1-azido-3-methylbenzene 
• 210159-14-1 5-methyl-1-(m-tolyl)-1H-1,2,3-triazole-4-carboxylic acid 

Downstream Products

• 950235-36-6 2-[5-methyl-1-(3-methylphenyl)-1H-1,2,3-triazol-4-yl]-5-phenyl-1,3,4-oxadiazole 
• 951902-71-9 2-[5-methyl-1-(3-methylphenyl)-1H-1,2,3-triazol-4-yl]-5-(2-methylphenyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Primary discovery of 1-aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as promising antimicrobial agents

Three series of novel 1H-1,2,3-triazole-4-carboxamides: 1-aryl-5-alkyl/aryl-1H-1,2,3-triazole-4-carboxamides, 1-aryl-5-amino-1H-1,2,3-triazole-4-carboxamides and 1,2,3-triazolo[1,5-a]quinazoline-3-carboxamides were synthesized via base-mediated click azide reactions. Compounds were evaluated for their antimicrobial activities against primary pathogens: Gram-positive and Gram-negative bacterial strains Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, as well as fungal strain Cryptococcus neoformans var. grubii and Candida albicans. Compounds exhibiting moderate to good activities were selected for SAR analysis. Several 5-methyl-1H-1,2,3-triazole-4-carboxamides 4d, 4l, 4r, showed potent antibacterial effect against S. aureus. On the contrary, 5-amino-1H-1,2,3-triazole-4-carboxamide 8b and [1,2,3]triazolo[1,5-a]quinazoline-3-carboxamide 9a were active against pathogenic yeast C. albicans. Thus, compound 4l under 1 μM demonstrated 50% growth inhibition against S. aureus. At the same concentration, the compound 9a killed approx. 40% of C. albicans cells. In general, these compounds demonstrated selective action and no significant impact on the viability of human keratinocytes of HaCaT line.

Synthesis of 1,2,4- and 1,3,4-oxadiazoles from 1-aryl-5-methyl-1H-1,2,3- triazole-4-carbonyl chlorides

5-Substituted 2-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazoles were synthesized by reaction of 1-aryl-5-methyl-1H-1,2,3-triazole-4-carbonyl chlorides with the corresponding 5-substituted 1H-tetrazoles. 5-Methyl-1-phenyl-1H-1,2,3-triazole-4-carb