88958-25-2Relevant academic research and scientific papers
Tri-Substituted Triazole-Enabled C-H Activation of Benzyl and Aryl Amines by Iron Catalysis
Shen, Zhigao,Cera, Gianpiero,Haven, Tobias,Ackermann, Lutz
supporting information, p. 3795 - 3798 (2017/07/26)
The design of trisubstituted triazoles set the stage for proximity-induced iron-catalyzed C-H activation of benzyl and aryl amines with ample scope. Thereby, C-H alkylations and C-H arylations proved viable with high levels of chemo and positional selectivities by means of racemization-free iron catalysis with the reusable triazole being removed in a traceless fashion.
Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors
Tang, Qidong,Wang, Linxiao,Tu, Yayi,Zhu, Wufu,Luo, Rong,Tu, Qidong,Wang, Ping,Wu, Chunjiang,Gong, Ping,Zheng, Pengwu
, p. 1680 - 1684 (2016/07/27)
A series of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 4 cancer cell lines (HT-29, A549, MCF-7, and PC-3) in vitro. Most compounds showed moderate to excellent potency, with the most promising analog 34 showing a c-Met IC50value of 1.68?nM. Structure–activity relationship studies indicated that electron-withdrawing groups (X?=?CF3, R1?=?F, R2?=?4-F) were required to decrease the higher electron density on the 5-atom linker to a proper degree to improve the inhibitory activity.
Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives
Pohodylo,Matiichuk,Obushak
, p. 275 - 279 (2014/04/17)
Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbocylic acid chlorides with tryptamine derivatives afforded substituted 1-aryl-N-[2-(1H-indol-3-yl) ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. At heating these compounds in toluene in the presence of POCl3 and P2O5 Bischler-Napieralski cyclization occurs giving 1-(1-aryl-5-methyl-1H-1,2,3- triazol-4-yl)-4,9-dihydro-3H-β-carbolines that can be transformed into β-carboline and tetrahydro-β-carboline derivatives.
Synthesis and crystal structure of new N,N′-Bis[1-(4-methoxyphenyl)- 5-methyl-1H-1,2,3-triazole-4-carbonyl]hydrazide
Dong, Heng-Shan,Wang, Yan-Fei,Dong, Hong-Ru,Wang, Bin,Quan, Bin
experimental part, p. 91 - 94 (2009/10/02)
The N,N′-bis[1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4- carbonyl]hydrazide 6 was synthesized from aryl triazole acids and its structure is established by MS, IR, and 1H NMR spectral data. Compound 6, C22H22N8O4, Mr = 462.48, crystallizes in the monoclinic space group P2(1)/c with unit cell parameters a = 15.3451(8), b = 8.6486(4), c = 16.8502(9) A, α = 90.00, β = 95.731(2), γ = 90.00°, V = 2225.1(2) A3, Z = 4, and Dx = 1.381 mg m-3. The final R was 0.0450. The four aromatic rings are close to linear because of N???H-N hydrogen bonds.
