31802-54-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-METHOXY-PHENYL)-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID is used as a potential drug candidate for its structural properties and possible biological activities. 1-(4-METHOXY-PHENYL)-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID's specific applications and potential benefits within the pharmaceutical industry are yet to be determined through further research and testing.

Upstream product

• 2101-87-3 p-methoxy-phenylazide 
• 141-97-9 ethyl acetoacetate 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1586765-20-9 1-[5-methyl-1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-6-fluoro-4,9-dihydro-3H-β-carboline 
• 1586765-14-1 5-methyl-1-(4-methoxyphenyl)-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide 
• 88958-25-2 5-methyl-1-(4-methoxyphenyl)-1,2,3-triazol-4-carbonyl chloride 

Relevant academic research and scientific papers

Design, synthesis and biological studies of some new imidazole-1,2,3-triazole hybrid derivatives

Some new 4-((1H-imidazol-1-yl)diarylmethyl)-5-methyl-1-aryl-1H-1,2,3-triazoles 7a-i were designed and synthesized by the one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanol compounds with 1H-imidazole. The new compounds 7a-i were ch

Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors

A series of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 4 cancer cell lines (HT-29, A549, MCF-7, and PC-3) in vitro. Most compounds showed moderate to excellent potency, with the most promising analog 34 showing a c-Met IC50value of 1.68?nM. Structure–activity relationship studies indicated that electron-withdrawing groups (X?=?CF3, R1?=?F, R2?=?4-F) were required to decrease the higher electron density on the 5-atom linker to a proper degree to improve the inhibitory activity.

Synthesis and antibacterial activity of di-heteryl substitued [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles

A new series of 3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles 12a-j have been prepared and assayed for their antibacterial activity against human pathogenic Gram-positive bacteria viz., Staphylococcus aureus, Bacillus subtilis and Gram-negative Escherichia coli. Among the screened compounds 12b, 12c and 12f, in which phenyl ring of triazole moiety bear 4-chloro, 4-nitro and 4-fluoro substituents respectively, showed high activity against all the micro-organisms employed. The activities of these compounds are almost equal to the standards.

Convenient and efficient synthesis of disubstituted piperazine derivatives by catalyst-free, atom-economical and tricomponent domino reactions

One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to the diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields. This protocol exhibits potential a

Synthesis and crystal structure of new N,N′-Bis[1-(4-methoxyphenyl)- 5-methyl-1H-1,2,3-triazole-4-carbonyl]hydrazide

The N,N′-bis[1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4- carbonyl]hydrazide 6 was synthesized from aryl triazole acids and its structure is established by MS, IR, and 1H NMR spectral data. Compound 6, C22H22N8O4, Mr = 462.48, crystallizes in the monoclinic space group P2(1)/c with unit cell parameters a = 15.3451(8), b = 8.6486(4), c = 16.8502(9) A, α = 90.00, β = 95.731(2), γ = 90.00°, V = 2225.1(2) A3, Z = 4, and Dx = 1.381 mg m-3. The final R was 0.0450. The four aromatic rings are close to linear because of N???H-N hydrogen bonds.

Synthesis of some novel 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,4-b]-1,3,4- thiadiazole derivatives

The cyclization of 1-amino-2-mercapto-5-[1-(4-ethoxyphenyl)-5-methyl-1,2,3- triazol-4-yl]-1,3,4-triazole which was synthesized from p-ethoxyaniline with various triazole acid in absolute phosphorus oxychloride yields 3,6-bis(1,2,3-triazolyl)-s-triazolo[3,

Studies on condensed heterocyclic compounds: Part XVIII-synthesis of 6- (1-aryl-5-methyl-1, 2, 3-triazol-4-yl)-3-(4-pyridyl)-s-triazolo[3,4-b]-1. 3, 4-thiadiazoles

Several new 6-(1-aryl-5-methyl-1, 2, 3-triazol-4-yl)-3-(4-pyridyl)-s- triazolo[3,4-b]-1, 3, 4-thiadiazoles 3a-j have been synthesized by the condensation of 4-amino-5-mercapto-3-(4-pyridyl)-1, 2, 4-triazole2 with 1- aryl-4-carboxy-5-methyl-1, 2, 3-triazoles 1a-j in the presence of phosphorus oxychloride. The structures of the products obtained are characterized by elemental analyses and spectral data and the fragmentation pattern of the mass spectra of 3a-j is discussed. 3a-j have been screened for their antibacterial activity against B. subtilis and E. coli.

1H and 13C NMR - Spectroscopy of substituted 1,2,3-triazoles

1-Aryl-4-carboxy-5-methyl-1,2,3-triazoles were prepared by the condensation of aryl azides with ethyl acetoacetate. The structures of these compounds were characterized by MS, IR and 1H and 13C NMR spectroscopy. The measured and calc