889586-78-1

Basic information

• Product Name: C₂₁H₂₁BrN₄OS
• Synonyms: C₂₁H₂₁BrN₄OS
• CAS NO: 889586-78-1
• Molecular Weight: 457.394
• Mol File: 889586-78-1.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁BrN₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁BrN₄OS(889586-78-1)
• EPA Substance Registry System: C₂₁H₂₁BrN₄OS(889586-78-1)

Safety Data

• Hazardous Substances Data: 889586-78-1(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 

Relevant articles and documents

Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs

A novel series of 2-acetamido- or 2-propanamido-4-(4-substituted phenyl)-1,3-thiazoles (11-34) was designed and synthesized. Compounds were subjected to National Cancer Institute (NCI) in vitro assessment for their antitumor activity, at a single dose of 10 μM. Most of the investigated compounds exhibited broad-spectrum antitumor activity. Compounds 19 and 28 believed to be the most active members in this study, with MG-MID GI 50, TGI, and LC50 values of 2.8, 11.4, 44.7; and 3.3, 13.1, 46.8, respectively. Compounds 19 and 28 proved to be nine and sevenfold more active than the standard antitumor drug 5-FU, respectively.