889670-19-3Relevant articles and documents
Catalyst-Free and Scalable Process for Synthesis of Novel MAP4K4 Inhibitor DMX-5804 and Its Glyco-Conjugates
Awasthi, Vibhudutta,Eeda, Venkateswararao
, p. 1658 - 1663 (2021)
DMX-5804 is a potent and selective mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) inhibitor, which is currently under evaluation for the treatment of myocardial infarction. Here, we report the process development of scalable and practica
MAP4K4 INHIBITORS
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Paragraph 00241; 00242, (2019/05/02)
This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, f
Syntheses of 1,3-disubstituted-5a-hydropyrrolo[2,3-d]quinazolino[3,2-e] pyrimidin-6(5H)-ones: A comparison of conventional and microwave technique
Augustine, Cicily,Agrawal
, p. 1653 - 1658 (2007/10/03)
An exclusive new ring system of 1,3-disubstituted-5a-hydropyrrolo[2,3-d] quinazolino [3,2-e]pyrimidin-6(5H)-ones 4 has been synthesised from 4-chloropyrrolo[2,3-d]pyrimidines 2 which are prepared using phase transfer catalysts. The synthesis 4 highlights