889670-19-3

Upstream product

• 64-18-6 formic acid 
• 115998-14-6 2-Amino-4-(4-methoxy-phenyl)-1-phenyl-1H-pyrrole-3-carbonitrile 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 62-53-3 aniline 
• 50-00-0 formaldehyd 

Downstream Products

• 507273-42-9 4-chloro-5-(4-methoxy-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Catalyst-Free and Scalable Process for Synthesis of Novel MAP4K4 Inhibitor DMX-5804 and Its Glyco-Conjugates

DMX-5804 is a potent and selective mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) inhibitor, which is currently under evaluation for the treatment of myocardial infarction. Here, we report the process development of scalable and practica

MAP4K4 INHIBITORS

This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, f

Syntheses of 1,3-disubstituted-5a-hydropyrrolo[2,3-d]quinazolino[3,2-e] pyrimidin-6(5H)-ones: A comparison of conventional and microwave technique

An exclusive new ring system of 1,3-disubstituted-5a-hydropyrrolo[2,3-d] quinazolino [3,2-e]pyrimidin-6(5H)-ones 4 has been synthesised from 4-chloropyrrolo[2,3-d]pyrimidines 2 which are prepared using phase transfer catalysts. The synthesis 4 highlights