889886-63-9

Upstream product

• 889885-19-2 (+/-)-9-[(1-(4-monomethoxytrityloxy)methyl)(3-(diisopropylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-17-0 (+/-)-9-[(1-(4-monomethoxytrityloxy)methyl)(3-tert-butylcarbonyloxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-18-1 (+/-)-9-[(1-(4-monomethoxytrityloxy)methyl)(3-hydroxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-15-8 (+/-)-9-[(1-tert-butyldimethylsilyloxymethyl)(3-pivaloyloxy)propyl]adenine 
• 889885-16-9 (+/-)-9-[(1-hydroxymethyl)(3-tert-butylcarbonyloxy)propyl]adenine 
• 889885-20-5 (+/-)-9-[(1-hydroxymethyl)(3-(diisopropylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 74-88-4 methyl iodide 

Downstream Products

• 889885-53-4 (+/-)-9-[(1-methoxymethyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 917240-82-5 (+/-)-9-[(1-methoxymethyl)(3-(di-isopropyloxycarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 
• 889885-44-3 (+/-)-9-[(1-methoxymethyl)(3-phosphonomethoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine 

Relevant academic research and scientific papers

Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents

□ Acyclic N9 adenine nucleosides substituted at C-1′ position were prepared by the Mitsunobu reaction of 1-tert-butyldimethylsilyl-4- pivaloylbutan-1,2,4-triol (5) with adenine. Pivaloyl hydroxyl was modified to the phosphonomethoxy derivatives, and the tert-butyldimethylsilyl hydroxyl was converted to methoxy, azido, amino, fluoro, and α-hydroxyethyl and was eliminated to give vinyl. The resulting phosphonic acids were converted to prodrugs also. Copyright Taylor & Francis Group, LLC.