917240-82-5Relevant articles and documents
Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents
Wu, Minwan,El-Kattan, Yahya,Lin, Tsu-Hsing,Ghosh, Ajit,Vadlakonda, Satish,Kotian, Pravin L.,Babu, Yarlagadda S.,Chand, Pooran
, p. 1543 - 1568 (2007/10/03)
□ Acyclic N9 adenine nucleosides substituted at C-1′ position were prepared by the Mitsunobu reaction of 1-tert-butyldimethylsilyl-4- pivaloylbutan-1,2,4-triol (5) with adenine. Pivaloyl hydroxyl was modified to the phosphonomethoxy derivatives, and the tert-butyldimethylsilyl hydroxyl was converted to methoxy, azido, amino, fluoro, and α-hydroxyethyl and was eliminated to give vinyl. The resulting phosphonic acids were converted to prodrugs also. Copyright Taylor & Francis Group, LLC.