88990-60-7Relevant academic research and scientific papers
C-Methylenation of anilines and indoles with CO2and hydrosilane using a pentanuclear zinc complex catalyst
Ema, Tadashi,Kosugi, Hiroyasu,Nishimura, Ritsuki,Takaishi, Kazuto,Yamada, Yuya
supporting information, p. 8083 - 8086 (2021/08/20)
The one-stepC-methylenation of anilines and indoles with CO2and phenylsilane was catalyzed by a pentanuclear ZnIIcomplex to give diarylmethanesviageminal C-H and C-C bond formation. It is proposed that the zinc-hydride complex generatedin situis a catalytically active species and that bis(silyl)acetal is a key intermediate. When aniline was used as a substrate, both theC-methylenation andN-methylation proceeded.
Effect of Substituents on the Reaction of Aromatic Amines and Formaldehyde in Acid Medium
Nayar, Mazhuvadyil R. Gopinathan,Francis, Joseph D.
, p. 776 - 780 (2007/10/02)
The kinetics and mechanism of the condensation of N- and C-substituted aromatic amines with formaldehyde in acid medium have been studied using quantitative TLC technique, and the first order rate constants and relative reactivities calculated.In all cases where para-position is free, 4-aminobenzyl alcohols are the initial products.These undergo condensation with amines to give 4-(4-aminobenzyl)anilines.The effect of substituents on the reactivity of amines has been discussed.
