1801711-87-4

Usage

Uses

Used in Pharmaceutical Applications:
1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carboxylic acid is used as an inhibitor of fungal and bacterial enzymes for its potential anti-fungal properties. Its unique structure and reactivity make it a valuable tool in drug development and chemical biology research.
Used in Chemical Biology Research:
1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carboxylic acid is used as a valuable tool in chemical biology research due to its unique structure and reactivity, which allows for exploration in coupling reactions and the development of new organic reactions.
Used in Organic Chemistry:
1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carboxylic acid is used in organic chemistry for its boronic acid moiety, which has been explored for use in coupling reactions and the development of new organic reactions, contributing to the advancement of synthetic chemistry.

Upstream product

• 148547-19-7 4-Bromo-3-methylbenzoic acid methyl ester 
• 473596-87-1 4-methoxycarbonyl-2-methylbenzeneboronic acid pinacol ester 
• 905710-66-9 4-bromo-3-(hydroxymethyl)benzonitrile 
• 905710-72-7 4-bromo-3-((methoxymethoxy)methyl)benzonitrile 
• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 160313-49-5 3-(dibromomethyl)-4-bromobenzonitrile 
• 89003-95-2 3-formaldehyde-4-bromobenzonitrile 
• 952041-75-7 methyl 3-formyl-4-(((trifluoromethyl)sulfonyl)oxy)benzoate 
• 24589-99-9 methyl 3-formyl-4-hydroxybenzoate 
• 584-87-2 3-formyl-4-hydroxybenzoic acid 

Relevant academic research and scientific papers

Reversible Covalent End-Capping of Collagen Model Peptides

The combination of supramolecular aggregation of collagen model peptides with reversible covalent end-capping of the formed triple helix in a single experimental set-up yielded minicollagens, which were characterized by a single melting temperature. In spite of the numerous possible reaction intermediates, a specific synthetic collagen with a leading, middle and trailing strand is formed in a highly cooperative self-assembly process.

Self-assembly of peptide boroxoles on cis-dihydroxylated oligoamide templates in water

We develop templates that can be used to stabilize consistent oligomers of a bioactive peptide. In the present study, we synthesize oligomers of an antibody epitope from the amyloidogenic prion protein. Dynamic covalent chemistry is the basis for the spontaneous condensation of 2, 3, 4 or 6 peptides with qualified polyol templates presenting the required number of bioorthogonal ligation sites. To study this process in aqueous solution, the N-terminal amino acid of a 13-mer peptide is first acylated with 4-carboxy-benzoboroxole (1-hydroxy-1,3-dihydrobenzo[c][1,2] oxaborole-5-carboxylic acid) and then mixed with the template to obtain self-assembled miniamyloids of specified degree of oligomerization. The template is assembled from bicyclic dipeptides of alternating d- and l-stereochemistry. The cis-diol group of this dipeptide hot=Tap (hot: d-hydroxythreonine, Tap: l-thiaproline) has sufficiently high affinity for boroxoles in water. A single N3-hot=Tap-OMe dipeptide template forms a 1?:?1 complex with 4-carboxy-benzoboroxole with excellent diastereoselectivity. The oligomeric template N3-(hot=Tap)n-OMe (n?=?2, 3, 4 or 6) presents a regular pattern of 2, 3, 4 or 6 cis-diol groups for the spontaneous esterification with the same number of boronic acids. Nuclear magnetic resonance identifies the homogenous regioselectivity and stereoselectivity of this ligation process. The combination of electron-poor benzoboroxoles with this optimized cis-diol template allows for the complete ligation under high-dilution conditions in water with only 1.3 equivalents of peptide-boroxole per diol functionality. Copyright

Boron-containing small molecule compound, and preparation method and application thereof

The invention discloses a novel compound with an anti-tumor effect as shown in a formula I, and a preparation method and application thereof. NOD-SCID mouse transplanted tumor model experiments show that the compounds can inhibit tumor growth. Further res

1-HYDROXY-1,3-DIHYDROBENZO[c][1,2]OXABOROLES AND THEIR USE AS HERBICIDES

Provided herein are 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaboroles and their derivatives, and compositions and methods of use thereof as herbicides.