890127-29-4Relevant academic research and scientific papers
Stereoselective synthesis of spirofused 3-substituted 2,3,4,4a,5,6- hexahydro-6H-benzo[c]quinolizine using the tert-amino effect
Deeva, Elisaveta V.,Glukhareva, Tatiana V.,Tkachev, Alexey V.,Morzherin, Yury Yu.
, p. 82 - 83 (2006)
The interaction of 2-(4-R-piperidino)benzaldehyde and cyclic CH-active compounds occurred as a tandem of Kn?venagel condensation and cyclization by tert-amino effect and led to spiro-fused 3-substituted 2,3,4,4a,5,6- hexahydro-6H-benzo[c]quinolizine.
Benzyl piperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as preparation method and application thereof
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Paragraph 0091-0095, (2021/08/25)
The invention belongs to the technical field of pharmacy, and particularly discloses a benzyl piperazine urea TRPV1 antagonistic and MOR agonistic double-target drug and a preparation method and application thereof, and particularly relates to a compound in general formula (I) and a pharmaceutically acceptable salt thereof, which can be used for preventing and/or treating diseases related to TRPV1 and/or MOR activity. , Immune dysfunction, neurological and psychiatric disorders, respiratory diseases, urinary and reproductive disorders. The invention also relates to a preparation method of the compounds and a pharmaceutical preparation containing the compounds.
