89013-65-0

Upstream product

• 21731-10-2 5-((2R,3R)-3,5,7-triacetoxychroman-2-yl)benzene-1 ,2,3-triyl triacetate 
• 970-73-0 epigallocatechin 
• 53901-95-4 p-acetoxycinnamoyl chloride 
• 27542-85-4 4-acetoxycinnamic acid 
• 183209-70-3 (-)-(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl acetate 
• 141222-28-8 (E)-3-(4'-((tert-butyldimethylsilyl)oxy)phenyl)acrylic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 120743-99-9 p-[(tert-butyldimethylsilyl)oxy]benzaldehyde 
• 1261480-13-0 (-)-epigallocatechin-3-gallate octa(tert-butyldimethylsilyl) ether 
• 848251-51-4 4-tert-butyldimethylsilyloxicinnamic acid 

Downstream Products

• 89013-68-3 (E)-(2R,3R)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-(4-methoxyphenyl)acrylate 

Relevant academic research and scientific papers

Preparation method and application of hydroxyl cinnamyl ester type catechin

The invention relates to a preparation method and application of hydroxyl cinnamyl ester type catechins. The hydroxyl cinnamyl ester type catechins comprise four catechins which are respectively namedas epicatechin trans-coumarate, epicatechin trans-caffeic acid ester, epigallocatechin trans-coumarate and epigallocatechin trans-caffeic acid ester. The hydroxyl cinnamyl ester type catechins are prepared by the following steps: carrying out four steps of full acetylation on epicatechin and epigallocatechin, removal of acetyl on phenolic hydroxyl, silanizing of phenolic hydroxyl and removal of 3-acetyl, then respectively esterifying with acetylated caffeic acid or coumaric acid acyl chloride, and removing a protecting group. The preparation method of the four catechins is simple and mild inconditions, and can be completed under general experimental conditions. The four hydroxycinnamyl ester type catechins have a certain inhibition effect on the activity of alpha-glucosidase, can be usedfor hypoglycemic drugs, and have important significance in the fields of agriculture and medicine.

The design, synthesis and biological evaluation of pro-EGCG derivatives as novel anti-vitiligo agents

With the aim of overcoming the instability and poor membrane permeability of epigallocatechin-3-gallate (EGCG), a series of prodrugs of EGCG and its derivatives (pro-EGCGs) were designed and synthesized, and their protective effect on melanocytes against

Caffeic acid derivatives in the treatment of leucoderma application (by machine translation)

The invention provides a coffee acid derivatives, the caffeic acid and derivatives with ester bond with the EGC connect into a prodrug, through the coffee acid and the EGC joint play activity, bioavailability is high, good treatment effect to vitiligo. (by machine translation)