89027-80-5

Upstream product

• 111-25-1 1-bromo-hexane 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 638-45-9 1-Iodohexane 
• 5736-94-7 4-(hexyloxy)benzaldehyde 
• 108-46-3 recorcinol 

Downstream Products

• 234431-50-6 (E)-4-(n-hexyloxy)-2-hydroxy-5-{[p-(n-tetradecyl)phenyl]azo}benzaldehyde 
• 1227625-48-0 (E)-4-(heptyloxy)phenyl 4-(4-(hexyloxy)-2-hydroxybenzylideneamino)benzoate 

Relevant academic research and scientific papers

Tunable emissive lanthanidomesogen derived from a room-temperature liquid-crystalline schiff-base ligand

A novel photoluminescent room-temperature liquid-crystalline salicylaldimine Schiff base with a short alkoxy substituent and a series of lanthanide(III) complexes of the type [Ln(LH)3(NO3) 3] (Ln=La, Pr, Sm, Gd, Tb, Dy; LH

A luminescent benzothiadiazole-bridging bis(salicylaldiminato)zinc(ii) complex with mechanochromic and organogelation properties

Herein, a new bis(salicylaldiminato)Zn(ii) Schiff base complex, BTZn, derived from benzo[c][1,2,5]thiadiazole-5,6-diamine was designed and synthesized. It exhibited unique mechanical force-induced luminescence change characteristic. Upon mechanical grindi

Photophysical behaviour of 4-hexyloxysalicylaldimies and their copper(II) complexes

Salicylaldimines are popular ligands used in the synthesis of anisotropic complexes which can form liquid crystal phases (metallomesogens). They tautomerise via exchange of the phenol proton, giving rise to solvent-dependent photophysical behaviour. In th

The influence of molecular flexibility on the mesogenic behavior of a new homologous series based on azo-azomethine: Synthesis, characterization, photoisomerization and DFT study

Through condensation of 2-hydroxy-4-n-alkoxybenzaldehyde (n = 2 to 8, 10, 12, 14, 16, 18) with (E)-4-((2,4-dimethylphenyl)diazenyl) benzene-1,3-diamine, new homologous series of rod shaped calamite liquid crystals based on azo-azomethine have been prepared. All synthesized compounds were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy. Use Differential Scanning Calorimeter (DSC) and Polarizing Optical Microscope (POM) to check the liquid crystal properties of all synthetic compounds. In the homologous series, all the compounds are mesogenic; some of them are in the nematic phase; some of them appear in the smectic A phase, and some appear in the nematic and smectic A phases. UV–vis pectroscopy was used to study the photoisomerization in chloroform. DFT (Density functional theory) level calculations and complete geometric optimization of all synthetic compounds are performed using B3LYP/6-31+G (d, p) basis sets.

Development of nematic and orthogonal smectic phases in short-core fluorinated hockey-stick shaped liquid crystal compounds

Here we report synthesis and investigations on novel short-core hockey-stick shaped molecules bearing a 4-n-alkyloxy-2-hydroxybenzylidene moiety at one end and polar fluoro-biphenyl moiety at the other end. The polar chloro and fluoro substituent at the lateral position of the core confers nematic and orthogonal smectic mesomorphism. The mesophase morphology is characterized by polarizing optical microscopy (POM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), electro-optical study and dielectric spectroscopy. The fluorinated compounds 1b (n = 16) and 1c (n = 18) have long terminal hydrocarbon tail and show orthogonal smectic phases with antiferroelectric switching behaviour. The chlorinated compound 2e (n = 8) with relatively short terminal chain length exhibits only a monotropic nematic phase on cooling. The nematic phase is comprised of cybotactic clusters as confirmed by XRD and exhibits electro-optic switching. The compound 2i (n = 12) manifests a short range enantiotropic nematic and additional orthogonal smectic phase. Dielectric spectroscopy reveals polar correlations in the nematic and smectic phases.

Chiral Bent-Shaped Molecules Exhibiting Unusually Wide Range of Blue Liquid-Crystalline Phases and Multistimuli-Responsive Behavior

Recently, an unprecedented observation of polar order, thermochromic behavior, and exotic mesophases in new chiral, bent-shaped systems with a ?CH3 moiety placed at the transverse position of the central core was reported. Herein, a homologous series of compounds with even-numbered carbon chains from n=4 to 18 were synthesized, in which ?Cl was substituted for ?CH3 at the kink position and a drastic modification in the phase structure of the bent-shaped molecule was observed. An unusual stabilization of the cubic blue phase (BP) over a wide range of 16.4 °C has been witnessed. Two homologues in this series (1-12 and 1-14) exhibit an interesting phase sequence consisting of BPI/II, chiral nematic, twist grain boundary, smectic A, and smectic X (SmX) phases. The higher homologues (1-16 and 1-18) stabilize the SmX phase enantiotropically over the entire temperature range. Crystal structure analysis confirmed the bent molecular architecture, with a bent angle of 148°, and revealed the presence of two different molecular conformations in an asymmetric unit of compound 1-4. A DFT study corroborated that the ?Cl moiety at the central core of the molecule led to an increase in the dipole moment along the transverse direction, which, in turn, facilitated the unusual stabilization of frustrated structures. Crystal polymorphism has been evidenced in three homologues (1-10, 1-12, and 1-14) of the series. On the application of mechanical pressure through grinding, compound 1-10 transformed from a bright yellow crystalline solid to a dark orange–green amorphous solid, which reversed upon dropwise addition of dichloromethane, indicating reversible mechanochromism in this class of compounds. In addition, excellent thermochromic behavior has been observed for compound 1-10 with a controlled temperature–color combination.

Synthesis, characterization, and mesomorphic properties of some new Schiff base homologues series and their Cu(II) complexes

In present study, we have synthesized two homologous series of some new Schiff base of 4-n-alkoxy-2-hydroxy benzaldehyde (n = 2–8, 10, 12, 14, 16, 18) with 4-amino acetanilide and their corresponding Cu(II) complexes. A series of new Schiff base containing two aromatic rings have been synthesized and characterized by various spectroanalytical techniques including FT-IR and 1H NMR. The mesomorphic properties of these compounds were observed by optical polarized light microscopy (POM) and confirmed by differential scanning calorimetry (DSC) study. It has been observed that all the newly synthesized compounds exhibit wide range SmA phase.

Schiff base of 4-n-alkoxy-2-hydroxy benzaldehyde with 4-amino acetophenone and their Cu(II) complexes: synthesis, characterization and mesomorphic behavior

New homologous series of Schiff’s base of 4-n-Alkoxy-2-hydroxy benzaldehyde (n = 2 to 8, 10, 12, 14, 16, 18) with 4-amino acetophenone and their Cu(II) metal complexes have been synthesized. The compounds were characterized using various spectroscopic techniques including FT-IR, 1H-NMR, 13C-NMR. Mesomorphic properties of these compounds have been investigated with polarizing optical microscope and differential scanning calorimeter. These compounds exhibit wide range SmA phase as confirmed by their typical optical texture under polarizing microscope.

METHODS OF TREATING CANCER WITH SMALL MOLECULE NF-kB INHIBITORS

The present invention provides, inter alia, compounds capable of inhibiting NF-κB. Pharmaceutical compositions containing and methods of using the compounds are also provided herein. Also provided are methods and kits for treating cancer and solid tumors in a subject, as well as methods and kits for inducing cancer cell death and apoptosis of a cancer cell, all utilizing the NF-κB inhibitors described herein.

Observation of polar order and thermochromic behaviour in a chiral bent-core system exhibiting exotic mesophases due to superstructural frustration

A new approach accompanied by superstructural frustration is reported. By attaching a cholesterol moiety directly to the central bent-core system it displayed exotic BPIII, BPII/I, Ncyb?, TGBA, SmAPA, SmA and SmX phases as shown by X-ray scattering results. While higher homologues of the series exhibited spontaneous formation of polar order (Ps ～ 61 nC cm-2) upon applied voltage, the lower homologues showed thermochromic behaviour which can also be trapped via temperature quenching.