890281-18-2

Basic information

• Product Name: C₁₄H₂₀N₂O₄S
• Synonyms: C₁₄H₂₀N₂O₄S
• CAS NO: 890281-18-2
• Molecular Weight: 312.39
• Mol File: 890281-18-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₂₀N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₂₀N₂O₄S(890281-18-2)
• EPA Substance Registry System: C₁₄H₂₀N₂O₄S(890281-18-2)

Safety Data

• Hazardous Substances Data: 890281-18-2(Hazardous Substances Data)

Upstream product

• 209667-59-4 tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylic acid 
• 259808-38-3 ethyl 2-(piperazin-1-yl)acetate hydrochloride 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 1305197-27-6 2-(4-benzenesulfonyl-piperazin-1-yl)-N-hydroxy-acetamide 

Relevant articles and documents

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors. A series of N-substituted 4-alkylpiperazine and 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.