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890302-02-0

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890302-02-0 Usage

General Description

2-Amino-6-(trifluoromethyl)nicotinic acid is a chemical compound with the molecular formula C8H6F3NO2. It is a derivative of nicotinic acid and contains a trifluoromethyl group. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other organic compounds. Additionally, 2-Amino-6-(trifluoromethyl)nicotinic acid has been studied for its potential biological activities, including its ability to inhibit enzymes and its potential use in the treatment of various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 890302-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,3,0 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 890302-02:
(8*8)+(7*9)+(6*0)+(5*3)+(4*0)+(3*2)+(2*0)+(1*2)=150
150 % 10 = 0
So 890302-02-0 is a valid CAS Registry Number.

890302-02-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-6-(Trifluoromethyl)nicotinic acid

1.2 Other means of identification

Product number -
Other names 2-amino-6-(trifluoromethyl)pyridine-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:890302-02-0 SDS

890302-02-0Downstream Products

890302-02-0Relevant articles and documents

Substituted fused pyrimidinone and dihydro-pyrimidone

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Paragraph 0182-0184, (2016/10/08)

The use of substituted fused pyrimidinones and dihydropyrimidinones of the formula (I) or salts thereof where the radicals of the formula (I) are each as defined in the description, for enhancing stress tolerance in plants to abiotic stress, and for invigorating plant growth and/or for increasing plant yield.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Thomas, Allen A.,Le Huerou,De Meese,Gunawardana, Indrani,Kaplan, Tomas,Romoff, Todd T.,Gonzales, Stephen S.,Condroski, Kevin,Boyd, Steven A.,Ballard, Josh,Bernat, Bryan,DeWolf, Walter,Han, May,Lee, Patrice,Lemieux, Christine,Pedersen, Robin,Pheneger, Jed,Poch, Greg,Smith, Darin,Sullivan, Francis,Weiler, Solly,Wright, S. Kirk,Lin, Jie,Brandhuber, Barb,Vigers, Guy

, p. 2206 - 2210 (2008/12/20)

Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3′-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes α-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described.

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