890315-74-9

Basic information

• Product Name: Benzoic acid, 2-(benzoylamino)-4-bromo-, methyl ester
• CAS NO: 890315-74-9
• Molecular Formula: C15H12BrNO3
• Molecular Weight: 334.169
• Mol File: 890315-74-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(benzoylamino)-4-bromo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(benzoylamino)-4-bromo-, methyl ester(890315-74-9)
• EPA Substance Registry System: Benzoic acid, 2-(benzoylamino)-4-bromo-, methyl ester(890315-74-9)

Safety Data

• Hazardous Substances Data: 890315-74-9(Hazardous Substances Data)

Upstream product

• 135484-83-2 2-amino-4-bromo-benzoic acid methyl ester 
• 98-88-4 benzoyl chloride 

Downstream Products

• 890315-33-0 methyl 2-(benzamido)-4-(1-methyl-1H-indol-5-yloxy)benzoate 
• 890315-87-4 methyl 2-(benzamido)-4-(2-(trimethylsilyl)ethynyl)benzoate 

Relevant articles and documents

Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.

NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF

An anthranilic acid derivative represented by the general formula (X) [wherein R1 represents hydrogen or a carboxy-protecting group; R2 represents optionally substituted phenyl, a heterocyclic group, etc.; R3 represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X1 represents carbonyl, etc.; X2 represents optionally substituted alkylene, a bond, etc.; X3 represents oxygen, a bond, etc.; and X4 represents a group represented by the general formula -X5-X6- or -X6-X5- (wherein X5 means oxygen, a bond, etc.; and X6 means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has an MMP-13 production inhibitory activity and is hence useful as a therapeutic agent for articular rheumatisum, osteoarthritis, cancer, etc.