890356-93-1

Upstream product

• 3320-86-3 2-nitrophenyl isocyanate 
• 109-73-9 N-butylamine 

Downstream Products

• 13201-86-0 N-(2-nitrophenyl)-N'-(2'-nitrophenyl)urea 

Relevant academic research and scientific papers

Preparation method of O-nitroaryl urea compound

The invention discloses a preparation method of an o-nitryl aryl urea compound, and the method comprises the following steps: adding carbodiimide as shown in a formula I and ceric ammonium nitrate as shown in a formula II into an organic solvent for reaction, and performing separating and purifying after the reaction is completed to obtain the o-nitryl aryl urea compound as shown in a formula III, wherein R1 is selected from alkyl, alkoxy, trifluoromethyl, halogen or ester group; R2 is selected from alkyl, alkenyl or alkynyl. Carbodiimide and ceric ammonium nitrate are used as basic raw materials, and different substituted urea nitro compounds are obtained in one step. The reaction raw materials are easy to prepare, and the atom economy is high; reaction conditions are mild, and operability is high; and the substrate universality is high.

Antiproliferative effects of novel urea derivatives against human prostate and lung cancer cells; And their inhibition of β-glucuronidase activity

Twenty-one novel urea derivatives were synthesized and their structures characterized by mass, NMR, IR, and UV spectroscopy. These compounds were evaluated for their antiproliferative profile against human PC-3 (prostate) and NCI-H460 (lung) cancer cell lines. Among them, compound 21 N-(3-nitrophenyl)- N′-(1-phenylethyl)urea was found to be active against both PC-3 (IC 50 ± SEM: 20.13 ± 0.91 μM) and NCI-H460 (GI 50: 22 ± 2.6 μM) cell lines; hence has the potential to be further studied as anticancer agent. These compounds were also investigated for their ability to inhibit urease, β-glucuronidase, and phosphodiesterase enzymes. N-(2,6-Dimethylphenyl)-N′-(4′-nitrophenyl)urea (1) demonstrated 90 % inhibition of β-glucuronidase enzyme (IC50 ± SEM: 3.38 ± 0.043 μM).

1,3-disubstituted ureas as antiglycating agents

Twenty one (21) 1,3-disubstituted urea derivatives were screened for their antiglycating potential and some of them displayed promising activity. Compound N-butyl-N'-(4-nitrophenyl)urea (6) and Nisopropyl-N'-(4-nitrophenyl)urea (18) exhibited excellent activity and could be investigated in search of medicines treating diabetes and associated complications.

Substituted urea derivatives: A potent class of antidepressant agents

A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'- phenylethyl)urea (1), demonstrat