89037-30-9

Basic information

• Product Name: 1-Propanone, 1,2-bis(4-methylphenyl)-, (S)-
• CAS NO: 89037-30-9
• Molecular Formula: C17H18O
• Molecular Weight: 238.329
• Mol File: 89037-30-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1,2-bis(4-methylphenyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1,2-bis(4-methylphenyl)-, (S)-(89037-30-9)
• EPA Substance Registry System: 1-Propanone, 1,2-bis(4-methylphenyl)-, (S)-(89037-30-9)

Safety Data

• Hazardous Substances Data: 89037-30-9(Hazardous Substances Data)

Upstream product

• 106-43-4 para-chlorotoluene 
• 5337-93-9 4'-methylpropiophenone 
• 108-88-3 toluene 
• 1204518-02-4 4-methylphenyl(2,4,6-trimethylphenyl)iodonium triflate 
• 188912-48-3 (Z)-trimethyl-(1-p-tolylprop-1-enyloxy)silane 
• 86433-02-5 (S)-1,1-bis(p-methylphenyl)-1,2-propanediol 
• 278188-16-2 α-ethenyl-α-(4-methylphenyl)-(4'-methylbenzene)methanol 

Relevant articles and documents

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.

Thianthrenation-enabled α-arylation of carbonyl compounds with arenes

The Pd-catalyzed α-arylation of carbonyl compounds with simple arenes enabled by site-selective thianthrenation has been demonstrated. This onepot process using thianthrenium salts as the traceless arylating reagents features mild conditions and a broad substrate scope. In addition, this protocol could also tolerate the heterocyclic carbonyl compounds and complex bioactive molecules, which is appealing for medicinal chemistry.

Fe(III)-mediated isomerization of α,α-diarylallylic alcohols to ketones: Via radical 1,2-aryl migration

An Fe(iii)-mediated radical 1,2-aryl migration of α,α-diarylallylic alcohols for the isomerization to ketones is described. The Fe(acac)3-silane would convert the alkene to an alkyl radical and initiates a 1,2-aryl migration-oxidation process. Thus Fe(acac)3 serves as an olefin hydrogen atom transfer initiator and oxidant, while various allylic alcohols could isomerize to ketones in moderate to good yields.