89048-58-8

Upstream product

• 72326-72-8 2-bromo-3,4,5-trimethoxy-1-methylbenzene 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 89048-14-6 1-(bromomethyl)-2,3,4,5-tetramethoxy-6-methylbenzene 
• 110-91-8 morpholine 
• 35896-58-3 2,3,4,5-tetramethoxytoluene 
• 89048-44-2 10-(2,3-dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoyl-L-arginine 
• 89048-26-0 2,3-dimethoxy-5-methyl-6-morpholinomethylhydroquinone 
• 3066-90-8 2,3-dimethoxy-5-methylbenzene-1,4-diol 
• 605-94-7 2,3-Dimethoxy-5-methyl-1,4-benzoquinone 

Downstream Products

• 89048-59-9 2,3-dimethoxy-5-methyl-6-morpholinomethyl-1,4-benzoquinone hydrochloride 

Relevant academic research and scientific papers

Efficient synthesis and antioxidant activities of N-heterocyclyl substituted Coenzyme Q analogues

A new strategy for the efficient synthesis of C-5 heterocyclyl substituted Coenzyme Q analogues was developed by N-alkylation of bromomethylated quinone 11 with a series of amines 12 under metal-free conditions. In vitro antioxidant activities of these Coenzyme Q analogues were evaluated and compared with commercial antioxidant Coenzyme Q10 by employing DPPH assay. All these N-heterocyclyl substituted Coenzyme Q analogues are found to be exhibiting good antioxidant properties and may be used as potent antioxidants for combating oxidative stress.

Efficient synthesis of 2,3-dimethoxy-5-methyl-6-morpholinomethyl-1,4-benzoquinone hydrochloride

The title compound (5) was prepared by a reaction sequence starting from 2,3,4,5-tetramethoxytoluene (1) via the Blanc reaction, oxidation and alkylation. The described method provides a good yield of the C-6 heterocyclic-substituted benzoquinone derivati

Synthesis and antioxidant activities of Coenzyme Q analogues

A series of 2,3-dimethoxy-5-methyl-1,4-benzoquinones (Coenzyme Q) substituted at the C-6 position with various groups were designed and synthesized based on the Coenzyme Q10 as potent antioxidant. In vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidant Coenzyme Q10 employing DPPH assay. All these synthesized Coenzyme Q analogues are found to exhibit good antioxidant activities. Of which Compound 8b bearing a N-benzoylpiperazine group at the C-6 position showed more potent inhibition of DPPH radical than Coenzyme Q10. All these results suggested the applicability of the Coenzyme Q analogues as potent antioxidants for combating oxidative stress.

Benzoquinone derivatives and production thereof

A novel benzoquinone derivative of the general formula: STR1 [wherein R1 and R2 are the same or different and each is methyl or methoxy; n is an integer of 0 to 21; m is 0 or 1, Z is a group of the formula: STR2 (wherein R3 and R4 are the same or different and each is hydrogen or an alkyl group which may optionally be substituted or, R3 and R4 together with the adjacent nitrogen atom form a morpholino group), a group of the formula: --COR5 (wherein R5 is an α-amino acid residue or a substituted or unsubstituted glucosamine residue), a group of the formula: STR3 (wherein R6 is a divalent hydrocarbon group of 1 to 3 carbon atoms), a group of the formula: STR4 (wherein R6 has the same meaning as defined above) or a group of the formula: --CH=CHl --COR7 (wherein l is an integer of 1 to 4 and R7 is hydroxy, methoxy or methyl)] has protocollagen-proline hydroxylase inhibiting activity, collagen biosynthesis inhibiting activity and 5-lipoxygenase suppressant activity, and is useful for the prevention and treatment of such diseases as pulmonary fibrosis, hepatocirrhosis, nephrosclerosis, arteriosclerosis, scleroderma, myelofibrosis and chronic arthritis or for the prevention and treatment of asthma, allergic rhinitis, urticaria, etc.