890529-41-6Relevant articles and documents
Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether
Kuethe, Jeffrey T.,Basu, Kallol,Orr, Robert K.,Ashley, Eric,Poirier, Marc,Tan, Lushi
, p. 938 - 944 (2018)
The evolution of a scalable process for the preparation of methylcyclobutanol-pyridyl ether 1 is described. Key aspects of this development including careful control of the stereochemistry, elimination of chromatography, and application to kilogram-scale
FUSED HETEROCYCLIC OR CARBOCYCLIC COMPOUNDS CARRYING A SUBSTITUTED CYCLOALIPHATIC RADICAL AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES
-
, (2016/03/19)
The present invention relates to novel fused heterocyclic or carbocyclic compounds of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising these compoun
PROTEIN KINASE INHIBITORS
-
Page/Page column 51; 52, (2015/06/08)
The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec or Src protein kinase families. The present invention also relates to the processes of preparation of these compounds, their intermediates, to the pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune, or infectious disease, disorders, or conditions in which protein kinase activity is implicated. More particularly, the present invention relates to a compound of Formula I.
2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION
-
Page/Page column 75-76, (2008/06/13)
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular