890573-84-9Relevant academic research and scientific papers
Efficient Direct Halogenation of Unsymmetrical N -Benzyl- and N -Phenylureas with Trihaloisocyanuric Acids
Sanabria, Carlos M.,Costa, Bruno B. S.,Viana, Gil M.,De Aguiar, Lúcia C. S.,De Mattos, Marcio C. S.
, p. 1359 - 1367 (2017/12/26)
A simple and efficient methodology for the direct halogenation of N -phenylureas was developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol proved to be effective for the construction of N -phenylureas with different patterns of substitution. Additionally, less reactive N -benzylureas were halogenated in the presence of a mixture of trifluoroacetic acid and acetonitrile at room temperature.
Highly Regioselective Iodination of N-Phenylureas with Iodine/Trichloroisocyanuric Acid
Sanabria, Carlos M.,do Casal, Mariana T.,De Souza, Raphael B. A.,De Aguiar, Lúcia C. S.,De Mattos, Marcio C. S.
, p. 1648 - 1654 (2017/03/21)
An efficient regioselective iodination of N-phenylureas was developed using iodine/trichloroisocyanuric acid in acetonitrile at room temperature. This protocol proved to be effective on a broad range of substituted N-phenylureas, forming the p-iodinated compounds in 65-96% yield under mild and neutral conditions.
The use of aqueous potassium dichloroiodate for the synthesis of ureas
Viana, Gil Mendes,De Sequeira Aguiar, Lúcia Cruz,De Araújo Ferr?o, Jonas,Simas, Alessandro Bolis Costa,Vasconcelos, Marcela Guariento
, p. 936 - 940 (2013/03/13)
We report a straightforward and efficient reaction protocol for the syntheses of substituted ureas via treatment of thioureas with aqueous potassium dichloroiodate (KICl2). By tuning the reaction condition, thioureas bearing activated N-aryl substituents may undergo either selective oxidation or sequential oxidation and iodination, forming iodoaryl ureas in the latter case.
