89069-63-6

Basic information

• Product Name: 3-(2-chlorophenyl)-2-phenylpyrimidin-4(3H)-one
• CAS NO: 89069-63-6
• Molecular Formula: C₁₆H₁₁ClN₂O
• Molecular Weight: 282.7243
• Mol File: 89069-63-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 421.9°C at 760 mmHg
• Flash Point: 208.9°C
• Density: 1.24g/cm³
• Vapor Pressure: 2.52E-07mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 3-(2-chlorophenyl)-2-phenylpyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-2-phenylpyrimidin-4(3H)-one(89069-63-6)
• EPA Substance Registry System: 3-(2-chlorophenyl)-2-phenylpyrimidin-4(3H)-one(89069-63-6)

Safety Data

• Hazardous Substances Data: 89069-63-6(Hazardous Substances Data)

Upstream product

• 58058-40-5 N-(2-chloro-phenyl)-benzamidine 

Relevant articles and documents

Synthesis and Biological Activity of 2,6-disubstituted 3-Aryl-4(3H)-pyrimidones as Potential CNS Agents

The reaction of N-arylamidines (III) with appropriate 2-alkynoic ester gives 2,6-disubstituted 3-aryl-4(3H)-pyrimidones (IV) in one step except in the reaction of N-(2-trifluoromethylphenyl/biphenyl)-S-methylisothiourea with ethyl propiolate, where the required pyrimidones (IVa17/IVa20) along with the adduct (Va/Vb) have been isolated; these adducts on cyclisation yield the corresponding pyrimidinones (IVa17/IVa20). 2,3,6-Triphenyl-4(3H)-pyrimidone (IVh1) on treatment with P2S5 furnishes the corresponding thione (VI).Some of these compounds have shown significant central muscle relaxant, hypnotic, anticonvulsant, CNS depressant, antiinflammatory and diuretic activities.