89082-76-8

Upstream product

• 141-97-9 ethyl acetoacetate 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 123486-01-1 6-cyclohexyl-3,6-dihydro-4-methyl-2-oxo-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester) 
• 958667-02-2 C₁₃H₂₂O₃ 
• 1124924-11-3 C₁₉H₃₉NO₄Si₂ 
• 1144506-25-1 C₂₁H₂₇NO₅ 
• 958667-07-7 C₁₅H₂₄O₄ 
• 112080-25-8 ethyl 4-cyclohexyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 112080-31-6 4-cyclohexyl-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 123486-05-5 4-cyclohexyl-1,4-dihydro-2-methoxy-6-methyl-5-pyrimidinecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

Microporous Lead-Organic Framework for Selective CO2 Adsorption and Heterogeneous Catalysis

A novel microporous metal-organic framework, {[Pb4(μ8-MTB)2(H2O)4]·5DMF·H2O}n (1; MTB = methanetetrabenzoate and DMF = N,N′-dimethylformamide), was successfully synthesized by a

Efficient and Reusable Pb(II) Metal–Organic Framework for Knoevenagel Condensation

A microporous lead–organic framework {[Pb4(μ8-MTB)2(H2O)4]·5DMF·H2O}n (MTB = methanetetrabenzoate, DMF = N,N′-dimethylformamide) was synthesized and studied as a catalyst in Knoevenagel condensation reactions. The framework is built from tetranuclear [Pb4(μ3-COO)(μ2-COO)6(COO)(H2O)4] clusters and exhibits a 3D structure, with repeated 1D jar-like cavities with sizes about 14.98 × 7.88 and 14.98 × 13.17??2 and BET specific surface area of 980?m2?g?1. To obtain open framework with unsaturated Pb(II) sites needed for catalysis, the thermal activation of the solvent exchanged sample was performed (DMF was exchanged by EtOH). The activated compound was tested in Knoevenagel condensation of bulky aldehydes and active methylene compounds at different temperatures. Excellent catalytic conversion and selectivity in condensation of small-sized aldehydes with malononitrile was observed, which indicates that the opened Pb(II) sites play a significant role in the heterogeneous catalytic process. Leaching test confirmed the stability of the catalyst in catalytic reactions. Moreover, the compound displayed good recyclability after several reuses without significant decrease in the original catalytic activity. Graphical Abstract: Novel Pb(II) metal–organic framework was tested in Knoevenagel condensation. The catalyst showed excellent catalytic conversion, selectivity and recyclability. Aldehydes with lower kinetic diameter demonstrated high conversions and yields. Catalyst is less efficient for condensation of larger aromatic aldehydes. [Figure not available: see fulltext.].

Comparison of the catalytic activity of MOFs and zeolites in Knoevenagel condensation

The catalytic behavior of metal-organic-frameworks (MOFs) CuBTC and FeBTC was investigated in Knoevenagel condensation of cyclohexane carbaldehyde and benzaldehyde with active methylene compounds and compared with zeolites BEA and TS-1. High yields were a

Domino imino-aldol-aza-Michael reaction: One-pot diastereo- and enantioselective synthesis of piperidines

Addition of α-arylmethylidene- or α-alkylidene-β-keto ester enolate to N-activated aldimines via the imino aldol pathway followed by intramolecular aza-Michael reaction in a domino fashion has been developed, and a highly diastereoselective route to subst

Synthesis of ethyl 5-hydroxyisoxazolidine-4-carboxylates via michael addition/intramolecular hemiketalisation

The 1,4-addition of N,O-bis(trimethylsilyl)hydroxylamine to alkylideneacetoacetates gave, in high yield, new 5-hydroxyisoxazolidine-4- carboxylates. The results of the accurate computational investigation on the mechanism at the DFT level are in complete

Enzymatic resolution of ethyl 3-hydroxy-2(1′substituted-methylidene)-butyrate by Pseudomonas cepacia lipase catalyzed acetylation

Enzymatic resolution of a series of enantiomerically pure ethyl 3-hydroxy-2(1′substituted-methylidene)-butyrates was performed using Pseudomonas cepacia lipase (EC 3.1.1.3) as a catalyst. Optically active ethyl 3-hydroxy-2(1′substituted-methylidene)-butyr