112080-31-6

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 4-cyclohexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-, ethyl ester
• CAS NO: 112080-31-6
• Molecular Formula: C14H22N2O3
• Molecular Weight: 266.34
• Mol File: 112080-31-6.mol

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 4-cyclohexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 4-cyclohexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-, ethyl ester(112080-31-6)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 4-cyclohexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-, ethyl ester(112080-31-6)

Safety Data

• Hazardous Substances Data: 112080-31-6(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 2043-61-0 cyclohexanecarbaldehyde 
• 89082-76-8 2-(cyclohexanylmethylene)-3-oxobutanoic acid ethyl ester 
• 123486-05-5 4-cyclohexyl-1,4-dihydro-2-methoxy-6-methyl-5-pyrimidinecarboxylic acid ethyl ester 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 

Relevant articles and documents

A practical and green approach towards synthesis of dihydropyrimidinones: Using heteropoly acids as efficient catalysts

A simple and green chemistry procedure for the synthesis of dihydropyrimidinones using heteropoly acid mediated cyclocondensation reaction is described. This method provides an efficient and much improved modification of the original Biginelli reaction re

ZnO Nanoparticles as an Efficient, Heterogeneous, Reusable, and Ecofriendly Catalyst for One-Pot, Three-Component Synthesis of 3,4-Dihydropyrimidin-2(1 H)-(thio)one Derivatives in Water

An extremely efficient heterogeneous protocol is reported for the one-pot, three-component synthesis of a series of dihydropyrimidinones (DHPMs) in the presence of ZnO nanoparticles in water as a green solvent. The ZnO nanoparticles exhibited excellent ca

Cu(OTf)2: A reusable catalyst for high-yield synthesis of 3,4-dihydropyrimidin-2(1H)-ones

Copper(II) triflate catalyzes efficiently the three-component condensation reaction of an aldehyde, β-ketoester and urea in acetonitrile to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones in high yields. The catalyst exhibited remarkable reusable activity.

Bismuth(III)-catalyzed synthesis of dihydropyrimidinones: Improved protocol conditions for the Biginelli reaction

An efficient synthesis of 3,4-dihydropyrimidines using bismuth chloride as a catalyst from an aldehyde, β-keto ester and urea in acetonitrile is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advan

Green Protocol for the Biginelli Three-Component Reaction: Ag 3PW12O40 as a Novel, Water-Tolerant Heteropolyacid for the Synthesis of 3,4-Dihydropyrimidinones

Biginelli three-component condensation of an aldehyde, β-keto ester, and urea proceeds smoothly on the surface of the silver salt of heteropolyacid (HPA), i.e. Ag3PW12O40, in water to afford the corresponding 3,4-dihydropy

Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction

In this report, an efficient high-yield method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli reaction with various aldehydes, β-ketoesters/β-diketones and urea/thiourea is described. The reaction was catalyze

Sulfonic Acid and Ionic Liquid Functionalized Covalent Organic Framework for Efficient Catalysis of the Biginelli Reaction

A quinoline-linked and ionic liquid-decorated covalent organic framework was prepared by incorporation of a multicomponent Povarov reaction and postsynthetic modification. The imidazolium and sulfonic acid-decorated COF-IM-SO3H can be a highly efficient B

NbCl5-catalyzed rapid and efficient synthesis of 3,4-dihydropyrimidinones under ambient conditions

Three-component condensation of an aldehyde, 1,3-dicarbonyl compound and urea or thiourea proceeds smoothly at room temperature in the presence of 5 mol % of NbCl5 under extremely mild conditions to afford the corresponding 3,4-dihydropyrimidin

Biginelli reactions catalyzed by hydrazine type organocatalyst

Pyrazolidine dihydrochloride can be used in the acceleration of Biginelli reactions between urea, ethyl acetoacetate and various aldehydes to provide DHPMs in good to excellent yields.

Ultrasound-accelerated synthesis of 3,4-dihydropyrimidin-2(1H)-ones with ceric ammonium nitrate

Ceric ammonium nitrate efficiently catalyzes the three component condensation of an aldehyde, β-ketoester and urea in methanol to afford the corresponding dihydropyrimidinones in excellent yields under sonication. Other oxidants such as manganese triaceta