890936-75-1

Upstream product

• 890936-74-0 (+)-11-benzyl-7,11-diazatricyclo[7.3.1.0^2,7]trideca-3-ene-6,12-dione 
• 890936-72-8 (5R)-(+)-1-benzyl-5-(bromomethyl)piperidin-2-one 
• 890936-70-6 methyl (3R)-1-benzyl-6-oxopiperidine-3-carboxylate 
• 890936-73-9 (3R)-(+)-1-[(1-benzyl-6-oxopiperidin-3-yl)methyl]pyridin-2(1H)-one 
• 156779-11-2 1-benzyl-6-oxopiperidine-3-carboxylic acid methyl ester 

Downstream Products

• 807310-56-1 (+)-N-benzylcytisine 

Relevant academic research and scientific papers

A Modular Approach to the Asymmetric Synthesis of Cytisine

The asymmetric synthesis of (+)-and (-)-cytisine starts with Matteson homologations for the construction of a chiral C3-building block. Conversion of the C3-building block into a dihydropyridone is achieved by straightforward functional group interconversions and ring closing metathesis. After bromination, this central building block was diastereospecifically converted into cytisine in five steps.

A flexible strategy for the synthesis of tri- and tetracyclic lupin alkaloids: Synthesis of (+)-cytisine, (±)-anagyrine, and (±)-thermopsine

(Chemical Equation Presented) Looping the lupin: A general synthetic strategy for the construction of the lupin alkaloids has been defined and involves sequential formation of the N1-C10 and C6-C7 bonds, which are common to compounds of this class of natu