891-87-2Relevant academic research and scientific papers
Improved synthesis of perfluoroalkyl substituted 1,3,4-oxadiazoles as precursors for corresponding 1,2,4-triazoles
Grünebaum, Mariano,Gerlitz, Anna I.,Buchheit, Annika,Jeschke, Steffen,Daniliuc, Constantin G.,Wiemh?fer, Hans-D.
, p. 30 - 35 (2017/03/31)
An improved and more efficient synthesis of 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole (2a), 2,5-bis(perfluoroethyl)-1,3,4-oxadiazole (2b), 2-(perfluoroethyl)-5-(trifluoromethyl)-1,3,4-oxadiazole (2d) and 2-(perfluoroheptyl)-5-(trifluoromethyl)-1,3,4-oxadi
Perfluoro-1,3,4-oxadiazoles
Vasiliev, N. V.,Lyashenko, Yu. E.,Patalakha, A. E.,Sokolski, G. A.
, p. 227 - 232 (2007/10/02)
Some new polyfluorinated 1,3,4-oxadiazoles have been obtained via a two-step method.The cycloadditions of the 1,3,4-oxadiazoles have been studied and an analysis of the energies of the frontier orbitals calculated by the MNDO method indicates a LUMO-dependent pathway for cycloaddition.
OXADIAZOLES WITH NF2-CONTAINING SUBSTITUENTS
John, Earnest Obed,Kirchmeier, Robert L.,Shreeve, Jean'ne M.
, p. 333 - 343 (2007/10/02)
Oxalyl chloride was reacted with sodium-5-(difluoroamino)-difluoromethyltetrazolate or sodium-5-pentafluoroethyltetrazolate to form f = NF2CF2 (7)>, and with F2NCF2C(NH2)=NOH to give 2 (5) which may be dehydrated to the 1,2,4-oxadiazole (6).Both sodium salts can be reacted with perfluoroacyl acid chlorides to form 2,5-disubstituted 1,3,4-oxadiazoles, where Rf'=NF2CF2 and Rf = CF3 (8), C2F5 (9) or C3F7 (10); Rf'= C2F5 and Rf = CF3 (11) or C2F5 (12).
