891005-41-7

Upstream product

• 158144-17-3 (1-methyl-pyrrol-2-yl)acetic acid hydrazide 
• 2493-02-9 4-bromophenyl isocyanate 
• 49669-45-6 ethyl (1-methyl-1H-pyrrol-2-yl)acetate 

Downstream Products

• 1217115-30-4 4-bromophenyl-3-[(1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1,2,4-triazolin-5-one 

Relevant academic research and scientific papers

Anticancer screening and structure activity relationship study of some semicarbazides and 1,2,4-Triazolin-5-ones

In this paper some semicarbazide and 1,2,4-triazolin-5-one derivatives are evaluated in vitro for their anticancer activity towards human tumour cell line: ovary (TOV 112D), lung (A 549), breast (T47D) and uterus (Hela). Compounds 2-4 have been found to s

Synthesis and RP HPLC studies of biologically active semicarbazides and their cyclic analogues 1,2,4-triazol-3-ones

The retention behaviour of semicarbazides and their cyclic analogues 1,2,4-triazol-3-ones, has been investigated by RP-8, RP-18 and IAM HPLC. The structures of new derivatives were proved by elemental analyses, IR, 1H NMR and 13C NMR

Synthesis, experimental and theoretical study on the structure of some semicarbazides with potential antibacterial activity

A series of 1,4-disubstituted semicarbazide and 4,4'-bis[1-substituted semicarbazide]diphenyl-methane derivatives were synthesized to explore their antibacterial activity. New compounds were characterized by elemental analysis and spectroscopic data. In order to find the tautomeric equilibrium for the molecules energy calculations for each possible tautomeric form of model compound 2, and for the most antibacterially active compound 7 in the investigated series, were calculated for the gas phase at the RHF/SCF/6-31G** level of theory.

Antioxidant evaluation of some semicarbazide, 1,2,4-triazolone and pyrazolone derivatives

1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone. The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).

Determination of the lipophilicity of some new derivatives of semicarbazide and 1,2,4-Triazol-5-one with potential antibacterial activity

The chromatographic behavior of new derivatives of 1,2,4-triazol-5-one and semicarbazide was determined. The lipophilicity was confirmed by the use of a RP-TLC method. The partition coefficients were calculated by use of theoretical procedures. The correl