891259-10-2Relevant academic research and scientific papers
Optimization of a series of potent and selective ketone histone deacetylase inhibitors
Pescatore, Giovanna,Kinzel, Olaf,Attenni, Barbara,Cecchetti, Ottavia,Fiore, Fabrizio,Fonsi, Massimiliano,Rowley, Michael,Schultz-Fademrecht, Carsten,Serafini, Sergio,Steinkuehler, Christian,Jones, Philip
scheme or table, p. 5528 - 5532 (2009/05/30)
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in the clinic. Herein we describe the optimization of a series of ketone small molecule HDAC inhibitors leading to potent and selective class I HDAC inhibitors with good dog PK.
