89128-07-4

Usage

Nitroimidazole derivative

A compound containing a nitro group and an imidazole ring This refers to the specific functional groups present in the structure, which give the compound its unique properties and reactivity.

Building block in organic synthesis

Used in the production of pharmaceuticals and agrochemicals This highlights the compound's role as an intermediate in the synthesis of various target molecules, particularly in the fields of medicine and agriculture.

Potential anti-parasitic and anti-microbial agent

Inhibits certain enzymes and biological processes in microorganisms This refers to the compound's ability to interfere with the normal functioning of parasites and microorganisms, making it a potential candidate for treating infections.

Corrosion inhibitor

Investigated for its potential application in protecting metal surfaces This indicates that the compound may have properties that can prevent or减缓 the corrosion of metals, which is important for maintaining the integrity and longevity of metal structures.

Versatile chemical

Various industrial and research applications This emphasizes the wide range of potential uses for 1-ETHYL-2-METHYL-4-NITRO-1H-IMIDAZOLE, making it a valuable compound in both industry and scientific research.

Upstream product

• 74-96-4 ethyl bromide 
• 696-23-1 2-methyl-5-nitro-1H-imidazole 
• 64-67-5 diethyl sulfate 
• 696-23-1 2-methyl-4-nitro-1H-imidazole 

Downstream Products

• 35681-66-4 1-Athyl-2-methyl-4-nitro-5-jodimidazol 

Relevant academic research and scientific papers

Transition-metal-catalyzed arylation of nitroimidazoles and further transformations of manipulable nitro group

Pd- or Ni-catalyzed C-H arylation of 4-nitroimidazole derivatives directed by a manipulable nitro group was developed. The reaction tolerates a wide range of substituted aryl halides and 4-nitroimidazoles. The experiments indicated that the nitro group has influence on regioselectivity of the reaction. In addition, we have shown that the efficiency of the Suzuki-Miyaura cross-coupling reaction of nitroimidazoles is slightly lower in comparison to the direct C-H arylation. The exploration of the chemical potential of the nitro group and a putative reaction mechanism are discussed.

Regioselective Alkylation of 4(5)-Nitro-1H-Imidazoles in Acidic Media: Study of Temperature Effects

Alkylation of 4(5)-nitro-1H-imidazoles in acidic media with reactive alkylating agents such as benzyl chloride and allyl bromide resulted in the predominant formation of the 5-nitro isomers at lower temperatures (75 deg C) and the 4-nitro isomers at higher temperatures (140 deg C).With less reactive alkylating agents, only the 5-nitro isomers were produced irrespective of temperature.The mechanism was shown to involve quaternization of the initially formed 1-alkyl-5-nitro-1H-imidazoles followed by preferential dealkylation to yield the thermodynamically more stable 4-nitro-1H-imidazoles.

Solid-liquid phase-transfer catalytic method for N-alkylation of nitroimidazole

A variety of 1-alkyl-2-methyl-4-nitroimidazoles have been synthesized with a solid-liquid phase-transfer catalytic method in excellent yields.

A facile high yielding method for synthesis of N-alkyl-4-nitroimidazoles

A high yielding and fast reaction for the synthesis of a variety of N-alkyl 4-nitroimidazoles has been described. This method involves reaction of 2-methyl-4(5)-nitro-1H-imidazole with suitable alkyl halides in K2CO3/DMF at 110-120°C.