89152-85-2 Usage
Description
C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE, a chemical compound with the molecular formula C11H13N3S, is a derivative of thiazole that features a methylamine group attached to the thiazole ring. C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE is known for its potential biological activities and pharmacological properties, making it a valuable component in the synthesis of various drugs and active pharmaceutical ingredients.
Uses
Used in Pharmaceutical Industry:
C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE is used as a key intermediate in the synthesis of various drugs and active pharmaceutical ingredients. Its unique structure and properties contribute to the development of new therapeutic agents with improved efficacy and safety profiles.
Used in Organic Synthesis and Chemical Research:
C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications. Its use in chemical research aids in the exploration of new reaction pathways and the discovery of novel chemical entities.
It is crucial to handle C-(2-M-TOLYL-THIAZOL-4-YL)-METHYLAMINE with care due to potential hazards associated with mishandling or improper use. Proper safety measures and guidelines should be followed to ensure the safe utilization of this compound in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 89152-85-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,1,5 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 89152-85:
(7*8)+(6*9)+(5*1)+(4*5)+(3*2)+(2*8)+(1*5)=162
162 % 10 = 2
So 89152-85-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2S/c1-8-3-2-4-9(5-8)11-13-10(6-12)7-14-11/h2-5,7H,6,12H2,1H3
89152-85-2Relevant articles and documents
Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety
Yan, Zhongzhong,Liu, Aiping,Ou, Yingcan,Li, Jianming,Yi,Zhang, Ning,Liu, Minhua,Huang, Lu,Ren, Jianwei,Liu, Weidong,Hu, Aixi
, p. 3218 - 3228 (2019/06/05)
Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.
