552331-06-3

Basic information

• Product Name: 6-BROMO-3-CHLOROISOQUINOLINE
• Synonyms: 6-BROMO-3-CHLOROISOQUINOLINE;6-Bromo-3-chloro-2-azanaphthalene;6-bromanyl-3-chloranyl-isoquinoline
• CAS NO: 552331-06-3
• Molecular Formula: C₉H₅BrClN
• Molecular Weight: 242.4997
• Product Categories: Building Blocks;Isoquinoline
• Mol File: 552331-06-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 349.497 °C at 760 mmHg
• Flash Point: 165.17 °C
• Appearance: /
• Density: 1.673 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.68
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.28±0.38(Predicted)
• CAS DataBase Reference: 6-BROMO-3-CHLOROISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-3-CHLOROISOQUINOLINE(552331-06-3)
• EPA Substance Registry System: 6-BROMO-3-CHLOROISOQUINOLINE(552331-06-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 552331-06-3(Hazardous Substances Data)

Usage

General Description

6-Bromo-3-chloroisoquinoline is a chemical compound that belongs to the isoquinoline family. It is a heterocyclic organic compound consisting of a six-membered ring containing one nitrogen atom. The compound is characterized by the presence of a bromine atom at the 6th position and a chlorine atom at the 3rd position on the isoquinoline ring. 6-Bromo-3-chloroisoquinoline has potential applications in pharmaceutical and agrochemical industries due to its unique structure and reactivity. It may be used as a building block in the synthesis of various bioactive compounds and may also exhibit antimicrobial and anticancer properties. Furthermore, it can serve as a valuable reagent in organic synthesis for the creation of diverse chemical compounds.

InChI:InChI=1/C9H5BrClN/c10-8-2-1-6-5-12-9(11)4-7(6)3-8/h1-5H

Upstream product

• 943749-63-1 4-bromo-2-(carboxymethyl)benzoic acid 
• 501130-49-0 6-bromoisoquinoline-1,3(2H,4H)-dione 
• 552331-05-2 6-bromo-1,3-dichloroisoquinoline 

Downstream Products

• 552331-36-9 6-trimethylstannylisoquinoline 
• 1256794-71-4 3-chloroisoquinoline-6-carboxylic acid 
• 1578482-64-0 N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-6-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazol-4-yl)isoquinolin-3-amine 
• 891785-93-6 {2-(1H-indol-3-yl)-1-[5-(3-phenylethynyl-isoquinolin-6-yl)-pyridin-3-yloxymethyl]-ethyl}-carbamic acid tert-butyl ester 
• 552332-12-4 {1-(1H-indol-3-ylmethyl)-2-[5-(3-phenyl-isoquinolin-6-yl)-pyridin-3-yloxy]-ethyl}-carbamic acid tert-butyl ester 
• 891785-28-7 6-bromo-isoquinolin-3-ylamine 
• 891785-30-1 6-bromo-3-fluoro-isoquinoline 
• 934343-53-0 benzyl-(6-bromo-isoquinolin-3-yl)-amine 

Relevant articles and documents

Synthesis of medical intermediate disubstituted N-containing heterocycle amine compound

The invention relates to synthesis of a medical intermediate disubstituted N-containing heterocycle amine compound. The synthesis comprises the following steps: reacting 5-bromo-2-carboxy-phenylaceticacid, urea and o-dichlorobenzene as raw materials to obtain 6-bromoisoquinoline-1, 3 (2H,4H)-dione; allowing the 6-bromoisoquinoline-1, 3 (2H,4H)-dione to react with phenyl dichloro sphosphineoxide,adding tetrahydrofuran to precipitate out, adjusting the pH value, and then passing through a column to obtain 1, 3-dichloro-6-bromoisoquinoline; then adding glacial acetic acid, red phosphorus and hydroiodic acid, and after the reaction, determining whether the reaction is complete or not by TLC, subjecting the filtrate and the filter cake to repeated fine treatment to obtain 3-chloro-6-bromoisoquinoline; adding copper sulfate pentahydrate, 6-bromo-3-chloroisoquinoline and a large amount of 15% ammonia water to react in a high-pressure kettle, extracting and passing column for many times according to different requirements to obtain the final product 3-chloro-6-aminoisoquinoline.

Kinase inhibitors

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.